7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol

Base Information

Chemical Name:7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol
CAS No.:1433663-13-8
Molecular Formula:C₂₄H₂₁F₂N₃O₃
Molecular Weight:437.446
Hs Code.:

Synonyms:7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol

Suppliers and Price of 7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of 7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol

There total 8 articles about 7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1433663-77-4
3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-5,6-dihydrobenzo[d]isoxazol-7(4H)-one

: 62351-47-7
3,5-difluorophenylmagnesium bromide

: 1433663-13-8
7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 5h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.7b00178

Reference yield:

: 1433663-62-7
3-(4-amino-3-methoxyphenyl)-5,6-dihydrobenzo[d]isoxazol-7(4H)-one

: 1433663-13-8
7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol

Guidance literature:: Multi-step reaction with 4 steps

1: acetic anhydride / 1 h / Cooling

2: caesium carbonate; potassium iodide / N,N-dimethyl-formamide; acetone / 55 °C

3: acetic acid / 95 °C / Inert atmosphere

4: tetrahydrofuran / 5 h / 0 °C

With acetic anhydride; caesium carbonate; acetic acid; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1433663-73-0
N-(2-methoxy-4-(7-oxo-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-yl)phenyl)-N-(2-oxopropyl)formamide

: 1433663-13-8
7-(3,5-difluorophenyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4,5,6,7-tetrahydrobenzo[d]isoxazol-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 95 °C / Inert atmosphere

2: tetrahydrofuran / 5 h / 0 °C

With acetic acid; In tetrahydrofuran;