tert-Butyl 4-(4-(5-chloro-2-hydroxyphenyl)pyridin-2-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 4-(4-(5-chloro-2-hydroxyphenyl)pyridin-2-yl)piperazine-1-carboxylate
CAS No.:1235407-20-1
Molecular Formula:C₂₀H₂₄ClN₃O₃
Molecular Weight:389.882
Hs Code.:

Synonyms:tert-Butyl 4-(4-(5-chloro-2-hydroxyphenyl)pyridin-2-yl)piperazine-1-carboxylate

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Chemical Property of tert-Butyl 4-(4-(5-chloro-2-hydroxyphenyl)pyridin-2-yl)piperazine-1-carboxylate

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Technology Process of tert-Butyl 4-(4-(5-chloro-2-hydroxyphenyl)pyridin-2-yl)piperazine-1-carboxylate

There total 1 articles about tert-Butyl 4-(4-(5-chloro-2-hydroxyphenyl)pyridin-2-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1197294-80-6
tert-butyl 4-(4-bromopyridin-2-yl)piperazine-1-carboxylate

: 89488-25-5
(5‐chloro‐2‐hydroxyphenyl)boronic acid

: 1235407-20-1
tert-Butyl 4-(4-(5-chloro-2-hydroxyphenyl)pyridin-2-yl)piperazine-1-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 70 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1235407-20-1
tert-Butyl 4-(4-(5-chloro-2-hydroxyphenyl)pyridin-2-yl)piperazine-1-carboxylate

: 1354786-52-9
5-chloro-2-fluoro-4-{[3-(2-piperazin-1-ylpyridin-4-yl)-4'-(trifluoromethyl)biphenyl-4-yl]oxy}-N-pyrimidin-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 18 h / 60 °C

2.1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 3 h / 130 °C / Microwave irradiation; Sealed tube

3.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 18 h / 60 °C / 2585.81 Torr

4.1: potassium carbonate / dimethyl sulfoxide / 20 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 20 h / 20 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydroxide; hydrogen; potassium carbonate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; 10 wt% Pd(OH)2 on carbon; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;

Reference yield:

: 1235407-20-1
tert-Butyl 4-(4-(5-chloro-2-hydroxyphenyl)pyridin-2-yl)piperazine-1-carboxylate

: 1354787-52-2
tert-Butyl 4-(4-(4-(2-chloro-4-(N-(2,4-dimethoxybenzyl)-N-(pyrimidin-2-yl)sulfamoyl)-5-fluorophenoxy)-4'-(trifluoromethyl)biphenyl-3-yl)pyridin-2-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 18 h / 60 °C

2.1: potassium carbonate; tetra(n-butyl)ammonium hydroxide / tri tert-butylphosphoniumtetrafluoroborate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide / N,N-dimethyl-formamide; methanol / 3 h / 130 °C / Microwave irradiation; Sealed tube

3.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 18 h / 60 °C / 2585.81 Torr

4.1: potassium carbonate / dimethyl sulfoxide / 20 h / 20 °C

With tetra(n-butyl)ammonium hydroxide; hydrogen; potassium carbonate; bis({5-chloro-2-[(4-chlorophenyl)(hydroxyimino)methyl]phenyl})cyclodipalladachl-orane-1,3,4-tris(ylium)-2-uide; 10 wt% Pd(OH)2 on carbon; tri tert-butylphosphoniumtetrafluoroborate; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;