73610-81-8

Upstream product

• 124126-66-5 α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate 
• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 
• 83816-96-0 (S)-2-((S)-4-Carboxy-4-{(S)-4-carboxy-4-[(S)-4-carboxy-4-(4-methylamino-benzoylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid 
• 30924-93-7 Boc-Glu-OBn 
• 83816-94-8 (S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-{(S)-4-benzyloxycarbonyl-4-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-butyrylamino}-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester 
• 83816-92-6 (S)-2-[(S)-4-Benzyloxycarbonyl-4-((S)-4-benzyloxycarbonyl-4-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester 
• 83816-93-7 N--L-glutamic acid tetrabenzyl ester hydrochloride 
• 56892-71-8 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride 
• 45120-30-7 L-glutamic acid α-tert-butyl ester 
• 19741-14-1 4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid 
• 84793-07-7 Fmoc-Glu-OtBu 
• 124126-68-7 α-tert-butyl N-<(9-fluorenylmethoxy)oxy>carbonyl-L-glutamic anhydride 

Relevant academic research and scientific papers

Folate analogues. 33. Synthesis of folate and antifolate poly-γ-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cel

Representative examples of folate and antifolate poly-γ-glutamyl metabolites were synthesized via the [(9-fluorenylmethoxy)oxy]carbonyl (Fmoc) chemistry using the KH polyamide resin. Polyglutamate yields were consistently better in all cases compared to t

A Synthetic Approach to Poly(γ-glutamyl) Conjugates of Methotrexate

Methotrexate poly(γ-L-glutamate)s bearing two and three glutamate units above that present in methotrexate have been synthesized by extension of a previously described route used to synthesize the lower conjugate bearing one added glutamate unit.Key steps