3-(((benzyloxy)carbonyl)amino)propyl acetate

Base Information

• Chemical Name: 3-(((benzyloxy)carbonyl)amino)propyl acetate
• CAS No.: 80662-87-9
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.282
• Mol file: 80662-87-9.mol

Synonyms:3-(((benzyloxy)carbonyl)amino)propyl acetate

Chemical Property of 3-(((benzyloxy)carbonyl)amino)propyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(((benzyloxy)carbonyl)amino)propyl acetate

There total 5 articles about 3-(((benzyloxy)carbonyl)amino)propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N-(benzyloxycarbonyl)acetamide potassium salt + 1-bromo-3-propanol (627-18-9) → 3-(((benzyloxy)carbonyl)amino)propyl acetate (80662-87-9)

Guidance literature:

With 18-crown-6 ether; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1055/s-0039-1690097

Reference yield:

3-[(N-benzyloxycarbonyl)amino]propanol (34637-22-4) + acetyl chloride (75-36-5) → 3-(((benzyloxy)carbonyl)amino)propyl acetate (80662-87-9)

Guidance literature:

With triethylamine; In dichloromethane; water;

Reference yield:

N-(benzyloxycarbonyl)acetamide (69261-50-3) → 3-(((benzyloxy)carbonyl)amino)propyl acetate (80662-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / 1,2-dimethoxyethane / 0.17 h / 0 °C

2: 18-crown-6 ether / acetonitrile / 4 h / 20 °C

With 18-crown-6 ether; potassium tert-butylate; In 1,2-dimethoxyethane; acetonitrile;

DOI:10.1055/s-0039-1690097

upstream raw materials:

acetic anhydride

benzyl diallylcarbamate

3-[(N-benzyloxycarbonyl)amino]propanol

acetyl chloride