5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride salt

Base Information

Chemical Name:5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride salt
CAS No.:1339944-50-1
Molecular Formula:C₁₇H₁₈ClFN₂O₄S*ClH
Molecular Weight:437.319
Hs Code.:

Synonyms:5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride salt

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Chemical Property of 5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride salt

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Technology Process of 5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride salt

There total 4 articles about 5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1339944-49-8
tert-butyl 4-(5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate

: 1339944-50-1
5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride salt

Guidance literature:: With hydrogenchloride; In water; for 0.25h; Product distribution / selectivity;

Reference yield:

: 103766-25-2
5-chloro-4-hydroxy-2(1H)-pyridinone

: 1339944-50-1
5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / N,N-dimethyl-formamide / 0.67 h

1.2: 0 - 60 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C / Inert atmosphere

2.2: 1 h / 130 °C

3.1: hydrogenchloride / water / 0.25 h

With hydrogenchloride; sodium hydride; triphenylphosphine; In water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1339944-50-1
5-chloro-1-(3-fluoro-4-(methylsulfonyl)phenyl)-4-(piperidin-4-yloxy)pyridin-2(1H)-one hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / N,N-dimethyl-formamide / 0.67 h

1.2: 0 - 60 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C / Inert atmosphere

2.2: 1 h / 130 °C

3.1: hydrogenchloride / water / 0.25 h

With hydrogenchloride; sodium hydride; triphenylphosphine; In water; N,N-dimethyl-formamide; mineral oil;