(R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate

Base Information

Chemical Name:(R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate
CAS No.:337971-05-8
Molecular Formula:C₁₇H₂₂O₄
Molecular Weight:290.359
Hs Code.:

Synonyms:(R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate

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Chemical Property of (R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate

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Technology Process of (R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate

There total 14 articles about (R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 98-88-4
benzoyl chloride

: 209474-16-8
(R)-(Z)-2-[5-(2-hydroxyethylidene)tetrahydropyran-2-yl]propan-2-ol

: 337971-05-8
(R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(00)01129-7

Reference yield:

: 209474-15-7
(R)-(Z)-2-[2-(2,2,5,5-tetramethyl[1,3]dioxolan-4-yl)ethyl]but-2-ene-1,4-diol

: 337971-05-8
(R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / pyridine / 2 h / 20 °C

2: 91 percent / p-TsOH; H₂O / methanol / 44 h / 20 - 50 °C

3: 1.179 g / pyridine / 15 h / 20 °C

4: K₂CO₃ / methanol / 1.5 h / 20 °C

5: 0.432 g / aq. NaOH / methanol / 20 h / 20 °C

6: 95 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; sodium hydroxide; water; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(00)01129-7

Reference yield:

: 337971-02-5
(R)-(Z)-2-(3,4-dihydroxy-4-methylpentyl)but-2-ene-1,4-diol bisbenzoate

: 337971-05-8
(R)-(Z)-2-[6-(1-hydroxy-1-methylethyl)tetrahydropyran-3-ylidene]ethyl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.179 g / pyridine / 15 h / 20 °C

2: K₂CO₃ / methanol / 1.5 h / 20 °C

3: 0.432 g / aq. NaOH / methanol / 20 h / 20 °C

4: 95 percent / triethylamine / CH₂Cl₂ / 12 h / 20 °C

With pyridine; sodium hydroxide; potassium carbonate; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(00)01129-7