3-[(S)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole

Base Information

Chemical Name:3-[(S)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole
CAS No.:1443532-37-3
Molecular Formula:C₃₄H₂₆FNO₄S₂
Molecular Weight:595.715
Hs Code.:

Synonyms:3-[(S)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole

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Chemical Property of 3-[(S)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole

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Technology Process of 3-[(S)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole

There total 3 articles about 3-[(S)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910650-82-7
1-fluoro-1,1-bis(phenylsulfonyl)methane

: 1099592-76-3
2-phenyl-3-(phenyl(tosyl)methyl)-1H-indole

: 1443532-36-2
3-[(R)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole

: 1443532-37-3
3-[(S)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole

Guidance literature:: With C₃₄H₄₅N₂O⁽¹⁺⁾*Br^(1-); caesium carbonate; In toluene; at -10 ℃; for 96h; Overall yield = 98 %; Overall yield = 58.8 mg; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol4013102

Reference yield:

: 3696-52-4
Ethyl-N-<α-(p-toluolsulfonyl)-benzyl>-carbamat

: 1443532-36-2
3-[(R)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole

: 1443532-37-3
3-[(S)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: indium(III) bromide / dichloromethane / 20 °C / Inert atmosphere

2: C₃₄H₄₅N₂O⁽¹⁺⁾*Br^(1-); caesium carbonate / toluene / -10 °C / Inert atmosphere

With indium(III) bromide; C₃₄H₄₅N₂O⁽¹⁺⁾*Br^(1-); caesium carbonate; In dichloromethane; toluene; 1: |Friedel-Crafts Alkylation;
DOI:10.1021/ol4013102

Reference yield:

: 100-52-7
benzaldehyde

: 1443532-36-2
3-[(R)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole

: 1443532-37-3
3-[(S)-2-fluoro-1-phenyl-2,2-bis(phenylsulfonyl)ethyl]-2-phenyl-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: formic acid / tetrahydrofuran; water / 20 °C / Inert atmosphere

2: indium(III) bromide / dichloromethane / 20 °C / Inert atmosphere

3: C₃₄H₄₅N₂O⁽¹⁺⁾*Br^(1-); caesium carbonate / toluene / -10 °C / Inert atmosphere

With formic acid; indium(III) bromide; C₃₄H₄₅N₂O⁽¹⁺⁾*Br^(1-); caesium carbonate; In tetrahydrofuran; dichloromethane; water; toluene; 2: |Friedel-Crafts Alkylation;
DOI:10.1021/ol4013102