2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile

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Chemical Name:2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile
CAS No.:1422207-25-7
Molecular Formula:C₃₁H₁₉ClFN₅
Molecular Weight:515.977
Hs Code.:

Synonyms:2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile

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Chemical Property of 2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile

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Technology Process of 2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile

There total 4 articles about 2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1319591-26-8
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-pyrazolo[3,4-b]pyridine

: 82671-02-1
2,6-dichloro-5-fluoro-pyridine-3-carbonitrile

: 1422207-25-7
2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; water; toluene; at 120 ℃; for 6h;
DOI:10.1021/jm301465a

Reference yield:

: 68618-36-0
3-Bromo-1H-pyrazolo<3,4-b>pyridine

: 1422207-25-7
2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 16 h / 105 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; methanol / 6 h / 120 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydride; sodium carbonate; In methanol; water; N,N-dimethyl-formamide; toluene; mineral oil; 3.1: |Suzuki Coupling;
DOI:10.1021/jm301465a

Reference yield:

: 76-83-5
trityl chloride

: 1422207-25-7
2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 16 h / 105 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; methanol / 6 h / 120 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydride; sodium carbonate; In methanol; water; N,N-dimethyl-formamide; toluene; mineral oil; 3.1: |Suzuki Coupling;
DOI:10.1021/jm301465a