68618-36-0

Basic information

• Product Name: 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-
• Synonyms: 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-;3-Bromo-1H-pyrazolo[3,4-b]pyridine ,97%;3-Bromo-1H-pyrazolo[3,4-b]pyridine;3-Bromo-1H-pyrazolo[3,4-b...;7-Aza-3-bromo-1H-indazole;3-Bromo-7-azaindazole;3-broMo-2h-pyrazolo[3,4-b]pyridine;3-Bromo-7-aza-1H-indazole
• CAS NO: 68618-36-0
• Molecular Formula: C₆H₄BrN₃
• Molecular Weight: 198.02006
• Mol File: 68618-36-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 170-171 °C
• Boiling Point: 356.229 °C at 760 mmHg
• Flash Point: 169.242 °C
• Appearance: /
• Density: 1.895 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.746
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.09±0.20(Predicted)
• CAS DataBase Reference: 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-(68618-36-0)
• EPA Substance Registry System: 1H-PYRAZOLO[3,4-B]PYRIDINE, 3-BROMO-(68618-36-0)

Safety Data

• Hazard Codes: T
• Statements: 25-20/21/22
• Safety Statements: 45-36/37
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 68618-36-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C6H4BrN3/c7-5-4-2-1-3-8-6(4)10-9-5/h1-3H,(H,8,9,10)

Upstream product

• 116855-08-4 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid 
• 1234616-46-6 tert-butyl 3-bromo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate 
• 36404-90-7 2-fluoropyridine-3-carboxaldehyde 
• 36404-88-3 2-chloro-3-carbaldehydepyridine 
• 63682-42-8 3-Diazapyrazolo<3,4-b>pyridine 
• 271-73-8 1H-Pyrazolo[3,4-b]pyridine 

Downstream Products

• 1319591-26-8 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-trityl-pyrazolo[3,4-b]pyridine 
• 1383446-20-5 N-((1R,3S)-3-((5-fluoro-2-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide 
• 1383447-03-7 N-((1R,3S)-3-((5-fluoro-2-(1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl)amino)cyclohexyl)-1-methyl-1H-imidazole-4-carboxamide 
• 116855-03-9 3-bromo-1-methyl-pyrazolo[3,4-b]pyridine 
• 65452-77-9 3-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 956010-88-1 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 1422207-25-7 2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile 

Relevant articles and documents

Decarboxylative Bromination of Heteroarenes: Initial Mechanistic Insights

After an initial report from our laboratory describing metal-free decarboxylative halogenation of various azaheteroarenes, we set out to investigate the possible mechanism by which this chemistry occurs. Evidence from this mechanistic investigation sugges

Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists

Several polar heteroaromatic acetic acids and their piperidine amides were synthesized and evaluated as ghrelin or type 1a growth hormone secretagogue receptor (GHS-R1a) inverse agonists. Efforts to improve pharmacokinetic and safety profile was achieved

PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.