(2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid

Base Information

• Chemical Name: (2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid
• CAS No.: 923580-07-8
• Molecular Formula: C₂₀H₁₄BrClFNO₂
• Molecular Weight: 434.692
• Mol file: 923580-07-8.mol

Synonyms:(2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid

Chemical Property of (2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid

There total 1 articles about (2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid (393509-04-1) → (2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid (923580-07-8)

Guidance literature:

[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid; With N-chloro-succinimide; In methanol; toluene; at 20 ℃; for 1h;

With acetic acid; In methanol; toluene; at 22 ℃; for 2h;

DOI:10.1021/ja0623358

Reference yield:

(2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid (923580-07-8) → [4-(4-chlorobenzyl)-7-fluoro-5-bromo-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid + [(3R)-5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid (393509-05-2)

Guidance literature:

With 1,1'-bis[(S)-4,5-dihydro-3H-binaphtho[2,1-c:1',2'-e]phosphino]ferrocene; hydrogen; triethylamine; Rh(cod)3⁽¹⁺⁾*BF₄^(1-); In methanol; at 50 ℃; for 20h; under 5430.05 Torr; Title compound not separated from byproducts;

DOI:10.1021/ja0623358

Reference yield:

(2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid (923580-07-8) → [5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid (393509-04-1)

Guidance literature:

With (R,S)-(3,5-CF₃Ph)2F-PXyl₂; hydrogen; triethylamine; Rh(cod)3⁽¹⁺⁾*BF₄^(1-); In methanol; at 50 ℃; for 20h; under 5430.05 Torr;

DOI:10.1021/ja0623358

upstream raw materials:

[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

Downstream raw materials:

[(3R)-5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid