Cyclopent[b]indole-3-acetic acid, 5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-

Base Information

• Chemical Name: Cyclopent[b]indole-3-acetic acid, 5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-
• CAS No.: 393509-04-1
• Molecular Formula: C20H16BrClFNO2
• Molecular Weight: 436.708
• Mol file: 393509-04-1.mol

Synonyms:

Chemical Property of Cyclopent[b]indole-3-acetic acid, 5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopent[b]indole-3-acetic acid, 5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-

There total 20 articles about Cyclopent[b]indole-3-acetic acid, 5-bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(5-bromo-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (393509-23-4) + bromoacid → [5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid (393509-04-1)

Guidance literature:

With sodium hydroxide; caesium carbonate; In ISOPROPYLAMIDE; water; 1-Chloro-4-(chloromethyl)benzene;

Reference yield:

(2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid (923580-07-8) → [5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid (393509-04-1)

Guidance literature:

With (R,S)-(3,5-CF₃Ph)2F-PXyl₂; hydrogen; triethylamine; Rh(cod)3⁽¹⁺⁾*BF₄^(1-); In methanol; at 50 ℃; for 20h; under 5430.05 Torr;

DOI:10.1021/ja0623358

Reference yield:

(5-bromo-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (393509-23-4) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → [5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid (393509-04-1)

Guidance literature:

(5-bromo-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid; 1-Chloro-4-(chloromethyl)benzene; With caesium carbonate; In ISOPROPYLAMIDE; at 50 ℃; for 20h;

With sodium hydroxide; water; In ISOPROPYLAMIDE; at 50 ℃; for 3h;

With hydrogenchloride; In Isopropyl acetate; at 15 ℃; pH=2;

upstream raw materials:

(2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid

(+/-) 2-(7-fluoro-1,2,3-trihydrocyclopenta[2,3-b]indol-3-yl)acetic acid

(5-bromo-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

[2-(2-bromo-4-fluoro-phenylimino)-cyclopentyl]-acetic acid ethyl ester

Downstream raw materials:

[(3R)-5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid

(2E)-[5-bromo-4-(4-chlorobenzyl)-7-fluoro-1,4-dihydrocyclopenta[b]indol-3(2H)-ylidene]acetic acid

C₁₂H₁₃N*C₂₀H₁₆BrClFNO₂

C₁₂H₁₃N*C₂₀H₁₆BrClFNO₂

Refernces

• 1、 -. "Method of Treating Pathological Blushing". Page/Page column 15. . Retrieved 2010/11/29.
• 2、 -. "NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT". . . Retrieved 2008/06/13.