tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate

Base Information

Chemical Name:tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate
CAS No.:1201187-44-1
Molecular Formula:C₁₈H₂₀N₄O₄S
Molecular Weight:388.447
Hs Code.:
Mol file:1201187-44-1.mol

Synonyms:N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester

Suppliers and Price of tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-ButylN-[5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamate
250mg
$ 220.00

Crysdot
tert-Butyl(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate 97%
1g
$ 1085.00

Chemenu
2-(Boc-amino)-5-tosyl-5H-pyrrolo[2,3-b]pyrazine 95%+
25g
$ 3098.00

Chemenu
2-(Boc-amino)-5-tosyl-5H-pyrrolo[2,3-b]pyrazine 95%+
10g
$ 1788.00

Chemenu
2-(Boc-amino)-5-tosyl-5H-pyrrolo[2,3-b]pyrazine 95%+
5g
$ 858.00

Chemenu
2-(Boc-amino)-5-tosyl-5H-pyrrolo[2,3-b]pyrazine 95%+
1g
$ 310.00

Total 68 raw suppliers

Chemical Property of tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate

Chemical Property:

PKA:9.45±0.43(Predicted)
Density:1.35±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

tert-ButylN-[5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses tert-Butyl N-[5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamate is a reagent in the synthetic preparation of tricyclic heterocycles and their kinase inhibitory activity. Preparation of novel nitrogen-containing tricyclic compounds as kinase inhibitors for treating immunological and oncological conditions.

Technology Process of tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate

There total 11 articles about tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 4248-19-5
tert-butyl carbazate

: 1201186-54-0
2-bromo-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine

: 1201187-44-1
N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester

Guidance literature:: With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 105 ℃; for 2.5h;

Reference yield: 54.0%

: 5-tosyl-5H-pyrrolo[2,3-b]pyrazine-2-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1201187-44-1
N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; at 70 ℃; for 16h;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1201187-44-1
N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium carbonate / 1,4-dioxane; tert-Amyl alcohol / 3 h / 95 °C

With palladium diacetate; sodium hydride; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; tert-Amyl alcohol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.108