(S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl-2',6'-dimethoxybiphenyl-2-yl(phenyl)phosphinate

Base Information

Chemical Name:(S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl-2',6'-dimethoxybiphenyl-2-yl(phenyl)phosphinate
CAS No.:1421840-50-7
Molecular Formula:C₃₅H₃₃ClNO₆PS
Molecular Weight:662.143
Hs Code.:

Synonyms:(S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl-2',6'-dimethoxybiphenyl-2-yl(phenyl)phosphinate

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Chemical Property of (S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl-2',6'-dimethoxybiphenyl-2-yl(phenyl)phosphinate

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Technology Process of (S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl-2',6'-dimethoxybiphenyl-2-yl(phenyl)phosphinate

There total 6 articles about (S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl-2',6'-dimethoxybiphenyl-2-yl(phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1421840-45-0
C₂₁H₁₉ClNO₄PS

: 755017-61-9
2'-bromo-2,6-dimethoxybiphenyl

: 1421840-50-7
(S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl-2',6'-dimethoxybiphenyl-2-yl(phenyl)phosphinate

Guidance literature:: 2'-bromo-2,6-dimethoxybiphenyl; With n-butyllithium; In tetrahydrofuran; hexane; at -70 - -20 ℃; Inert atmosphere;

C₂₁H₁₉ClNO₄PS; In tetrahydrofuran; hexane; at -70 - -20 ℃; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; hexane; Inert atmosphere;
DOI:10.1021/ja312352p

Reference yield:

: 824-72-6
P,P-dichlorophenylphosphine oxide

: 1421840-50-7
(S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl-2',6'-dimethoxybiphenyl-2-yl(phenyl)phosphinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3,5-Lutidine / dichloromethane / -10 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / -70 - -20 °C / Inert atmosphere

2.2: -70 - -20 °C / Inert atmosphere

2.3: Inert atmosphere

With 3,5-Lutidine; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja312352p

Reference yield:

: 1421840-44-9
(R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide

: 1421840-50-7
(S)-4-chloro-2-[(1R)-1-{[(4-methylphenyl)sulfonyl]amino}ethyl]phenyl-2',6'-dimethoxybiphenyl-2-yl(phenyl)phosphinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3,5-Lutidine / dichloromethane / -10 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / -70 - -20 °C / Inert atmosphere

2.2: -70 - -20 °C / Inert atmosphere

2.3: Inert atmosphere

With 3,5-Lutidine; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja312352p