(6S,9S,12S)-9-((benzoyloxy)methyl)-6,12-di((S)-sec-butyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid

Base Information

Chemical Name:(6S,9S,12S)-9-((benzoyloxy)methyl)-6,12-di((S)-sec-butyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid
CAS No.:1427166-50-4
Molecular Formula:C₂₇H₄₃N₃O₇
Molecular Weight:521.654
Hs Code.:

Synonyms:(6S,9S,12S)-9-((benzoyloxy)methyl)-6,12-di((S)-sec-butyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid

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Chemical Property of (6S,9S,12S)-9-((benzoyloxy)methyl)-6,12-di((S)-sec-butyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid

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Technology Process of (6S,9S,12S)-9-((benzoyloxy)methyl)-6,12-di((S)-sec-butyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid

There total 4 articles about (6S,9S,12S)-9-((benzoyloxy)methyl)-6,12-di((S)-sec-butyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1427166-54-8
(S)-3-(benzyloxy)-1-(((1S,2S)-1-carboxy-2-methylbutyl)amino)-1-oxopropan-2-aminium chloride

: 1414706-24-3
tert-butyl ((2S,3S)-1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-methyl-1-oxopentan-2-yl)carbamate

: 1427166-50-4
(6S,9S,12S)-9-((benzoyloxy)methyl)-6,12-di((S)-sec-butyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 ℃; for 1.5h; Microwave irradiation;
DOI:10.1039/c3cc39291k

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 1427166-50-4
(6S,9S,12S)-9-((benzoyloxy)methyl)-6,12-di((S)-sec-butyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / Inert atmosphere

1.2: 12 h / 25 °C / Inert atmosphere

2.1: triethylamine / acetonitrile; water / 16 h

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 25 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1.5 h / 50 °C / Microwave irradiation

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1039/c3cc39291k

Reference yield:

: 1072841-05-4
(S)-tert-butyl (1-(1H-benzo[d][1,2,3]triazol-1-yl)-3-(benzyloxy)-1-oxopropan-2-yl)carbamate

: 1427166-50-4
(6S,9S,12S)-9-((benzoyloxy)methyl)-6,12-di((S)-sec-butyl)-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile; water / 16 h

2: hydrogenchloride / 1,4-dioxane / 3 h / 25 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 1.5 h / 50 °C / Microwave irradiation

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; acetonitrile;
DOI:10.1039/c3cc39291k