N-<<1-benzyl-5-<(N-phenyl,N-propionyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide

Base Information

Chemical Name:N-<<1-benzyl-5-<(N-phenyl,N-propionyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide
CAS No.:145474-78-8
Molecular Formula:C₃₀H₃₄FN₃O₂
Molecular Weight:487.617
Hs Code.:

Synonyms:N-<<1-benzyl-5-<(N-phenyl,N-propionyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide

Suppliers and Price of N-<<1-benzyl-5-<(N-phenyl,N-propionyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<<1-benzyl-5-<(N-phenyl,N-propionyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide

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Technology Process of N-<<1-benzyl-5-<(N-phenyl,N-propionyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide

There total 10 articles about N-<<1-benzyl-5-<(N-phenyl,N-propionyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 79-03-8
propionyl chloride

: 145474-80-2,145474-86-8
N-<<1-benzyl-5-<(N-phenyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide

: 145474-78-8
N-<<1-benzyl-5-<(N-phenyl,N-propionyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.75h;
DOI:10.1016/S0040-4020(01)81192-3

Reference yield: 17.0%

: 620-71-3
N-(phenyl)-2-methylacetamide

: 145474-72-2,145474-74-4
N-<<1-benzyl-5-<(4-methylphenyl)sulfonyloxymethyl>-2-piperidinyl>methyl>-4-fluorobenzamide

: 145474-78-8
N-<<1-benzyl-5-<(N-phenyl,N-propionyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide

Guidance literature:: With 18-crown-6 ether; potassium tert-butylate; In toluene; at 70 ℃; for 24h;
DOI:10.1016/S0040-4020(01)81192-3

Reference yield:

: 72551-53-2
ethyl 1-benzylpiperidine-3-carboxylate

: 145474-78-8
N-<<1-benzyl-5-<(N-phenyl,N-propionyl)aminomethyl>-2-piperidinyl>methyl>-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) mercuric acetate / 1.) aq. acetic acid, 90 deg C, 6 h; 2.) aq. acetic acid (pH 5), r.t. 1 h

2: LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

3: NEt₃ / CH₂Cl₂ / 1 h / Ambient temperature

4: 79 percent / KOt-Bu / methanol / 16 h / Ambient temperature

5: NEt₃, SO₃/pyridine / dimethylsulfoxide / 1 h / Ambient temperature

6: NaCNBH₃, 2n HCl / methanol / pH = 6, 1.) r.t., 15 min., 2.) reflux, 30 min.

7: 89 percent / NEt₃ / CH₂Cl₂ / 0.75 h / 0 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; sulfur trioxide; potassium tert-butylate; mercury(II) diacetate; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(01)81192-3