O-{(1S)-[3-(2,3,6-trimethyl-phenyl)-isoxazol-5-yl]-ethyl}-hydroxylamine

Base Information

Chemical Name:O-{(1S)-[3-(2,3,6-trimethyl-phenyl)-isoxazol-5-yl]-ethyl}-hydroxylamine
CAS No.:782450-79-7
Molecular Formula:C₁₄H₁₈N₂O₂
Molecular Weight:246.309
Hs Code.:

Synonyms:O-{(1S)-[3-(2,3,6-trimethyl-phenyl)-isoxazol-5-yl]-ethyl}-hydroxylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O-{(1S)-[3-(2,3,6-trimethyl-phenyl)-isoxazol-5-yl]-ethyl}-hydroxylamine

Chemical Property:

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Technology Process of O-{(1S)-[3-(2,3,6-trimethyl-phenyl)-isoxazol-5-yl]-ethyl}-hydroxylamine

There total 3 articles about O-{(1S)-[3-(2,3,6-trimethyl-phenyl)-isoxazol-5-yl]-ethyl}-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 2914-69-4
(S)-(-)-3-butyn-2-ol

: 40188-34-9
2,4,6-trimethylbenzaldehyde oxime

: 782450-79-7
O-{(1S)-[3-(2,3,6-trimethyl-phenyl)-isoxazol-5-yl]-ethyl}-hydroxylamine

Guidance literature:: (S)-(-)-3-butyn-2-ol; With polystyrene-bound N-hydroxyphthalimide resin; tributylphosphine; diamide; In tetrahydrofuran; dichloromethane; at 20 ℃;

2,4,6-trimethylbenzaldehyde oxime; With N-Bromosuccinimide; sodium hydrogencarbonate; In dichloromethane; at 35 ℃;

With hydrazine; In dichloromethane;
DOI:10.1016/j.tet.2004.05.109

Reference yield:

: 2-{(S)-1-[3-(2,4,6-Trimethyl-phenyl)-isoxazol-5-yl]-ethoxy}-isoindole-1,3-dione

: 782450-79-7
O-{(1S)-[3-(2,3,6-trimethyl-phenyl)-isoxazol-5-yl]-ethyl}-hydroxylamine

Guidance literature:: With PS-diethylenetriamine; In dichloromethane;
DOI:10.1021/ol051023r

Reference yield:

: 487-68-3
mesytaldehyde

: 782450-79-7
O-{(1S)-[3-(2,3,6-trimethyl-phenyl)-isoxazol-5-yl]-ethyl}-hydroxylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; Et₃N / CH₂Cl₂

1.2: aq. HCl / CH₂Cl₂

2.1: polystyrene-bound N-hydroxyphthalimide resin; azodicarboxylic acid bis[dimethylamide]; P(n-Bu)3 / CH₂Cl₂; tetrahydrofuran / 20 °C

2.2: NBS; NaHCO₃ / CH₂Cl₂ / 35 °C

2.3: 93 percent / NH₂NH₂ / CH₂Cl₂

With polystyrene-bound N-hydroxyphthalimide resin; tributylphosphine; diamide; hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2004.05.109