tert-butyl-2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-biphenyl thiopropionate

Base Information

Chemical Name:tert-butyl-2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-biphenyl thiopropionate
CAS No.:427895-04-3
Molecular Formula:C₂₈H₂₉N₃O₃S
Molecular Weight:487.623
Hs Code.:

Synonyms:tert-butyl-2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-biphenyl thiopropionate

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Chemical Property of tert-butyl-2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-biphenyl thiopropionate

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Technology Process of tert-butyl-2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-biphenyl thiopropionate

There total 9 articles about tert-butyl-2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-biphenyl thiopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 960-16-7
tributylphenylstannane

: 427895-03-2
tert-butyl-2-[2-(4-oxo-4H-benzo[d][1,2,3]-triazin-3-ylethyl)]-3-(4-bromo-phenylthio)propionate

: 427895-04-3
tert-butyl-2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-biphenyl thiopropionate

Guidance literature:: With lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 12h; Heating;
DOI:10.1016/S0968-0896(01)00311-X

Reference yield:

: 7338-27-4
4-methoxy-2-methylene-4-oxobutanoic acid

: 427895-04-3
tert-butyl-2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-biphenyl thiopropionate

Guidance literature:: Multi-step reaction with 7 steps

1: 67.5 percent / H₂SO₄ / CH₂Cl₂ / 0 - 20 °C

2: 75.3 percent / LiOH / H₂O; dioxane / 2.5 h / 0 - 20 °C

3: 80.2 percent / NaOMe / methanol / 20 °C

4: N-methylmorpholine / 1,2-dimethoxy-ethane / 20 °C

5: 34 g / NaBH₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / -10 °C

6: 88 percent / Ph₃P; DIAD / tetrahydrofuran / 1.5 h / 0 - 20 °C

7: 63 percent / LiCl / Pd(PPh₃)4 / toluene / 12 h / Heating

With 4-methyl-morpholine; lithium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; sulfuric acid; sodium methylate; triphenylphosphine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; 6: Mitsunobu reaction / 7: Stille reaction;
DOI:10.1016/S0968-0896(01)00311-X

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 427895-04-3
tert-butyl-2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-biphenyl thiopropionate

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / Amberlyst 15 H⁺ resin / 72 h / 20 °C

2: 67.5 percent / H₂SO₄ / CH₂Cl₂ / 0 - 20 °C

3: 75.3 percent / LiOH / H₂O; dioxane / 2.5 h / 0 - 20 °C

4: 80.2 percent / NaOMe / methanol / 20 °C

5: N-methylmorpholine / 1,2-dimethoxy-ethane / 20 °C

6: 34 g / NaBH₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / -10 °C

7: 88 percent / Ph₃P; DIAD / tetrahydrofuran / 1.5 h / 0 - 20 °C

8: 63 percent / LiCl / Pd(PPh₃)4 / toluene / 12 h / Heating

With 4-methyl-morpholine; lithium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; Amberlyst 15 H⁺ resin; sulfuric acid; sodium methylate; triphenylphosphine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; 7: Mitsunobu reaction / 8: Stille reaction;
DOI:10.1016/S0968-0896(01)00311-X