2-Methoxypyridine-4-carbonyl chloride

Base Information

• Chemical Name: 2-Methoxypyridine-4-carbonyl chloride
• CAS No.: 193538-79-3
• Molecular Formula: C7H6 Cl N O2
• Molecular Weight: 171.583
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70598368
• Wikidata: Q82494117
• Mol file: 193538-79-3.mol

Synonyms:193538-79-3;2-methoxyisonicotinoyl chloride;2-Methoxypyridine-4-carbonyl chloride;4-Pyridinecarbonyl chloride, 2-methoxy- (9CI);2-methoxyisonicotinoylchloride;SCHEMBL2431121;2-Methoxy-isonicotinoyl chloride;DTXSID70598368;NDNSYURGNSEPDJ-UHFFFAOYSA-N;DB-324023

Chemical Property of 2-Methoxypyridine-4-carbonyl chloride

Chemical Property:

• PSA: 39.19000
• LogP: 1.46920
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 171.0087061
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

99%, ^*data from raw suppliers

2-Methoxyisonicotinoyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC=CC(=C1)C(=O)Cl

Technology Process of 2-Methoxypyridine-4-carbonyl chloride

There total 1 articles about 2-Methoxypyridine-4-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2-methoxy-isonicotinic acid (105596-63-2) → 2-methoxypyridine-4-carbonyl chloride (193538-79-3)

Guidance literature:

With thionyl chloride; In toluene; at 80 ℃; for 3h; Inert atmosphere;

Reference yield: 45.0%

2-methoxypyridine-4-carbonyl chloride (193538-79-3) + N,2-dimethyl-4-[6-(trifluoromethyl)quinazolin-2-yl]aniline → 2-methoxy-N-methyl-N-(2-methyl-4-(6-(trifluoromethyl)quinazolin-2-yl)phenyl)isonicotinamide

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

2-methoxypyridine-4-carbonyl chloride (193538-79-3) + diazomethyl-trimethyl-silane (18107-18-1) → 2-bromo-1-(2-methoxypyridin-4-yl)ethanone (1187669-32-4)

Guidance literature:

2-methoxypyridine-4-carbonyl chloride; diazomethyl-trimethyl-silane; In tetrahydrofuran; Petroleum ether; at 0 ℃;

With hydrogen bromide; In tetrahydrofuran; water; Petroleum ether; at 20 ℃;

With potassium hydrogencarbonate; In tetrahydrofuran; water; Petroleum ether; Saturated solution;

upstream raw materials:

2-methoxy-isonicotinic acid

Downstream raw materials:

2-bromo-1-(2-methoxypyridin-4-yl)ethanone