3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine

Base Information

• Chemical Name: 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine
• CAS No.: 1146973-47-8
• Molecular Formula: C₂₀H₁₃F₃N₂
• Molecular Weight: 338.332
• Mol file: 1146973-47-8.mol

Synonyms:3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine

Chemical Property of 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine

There total 7 articles about 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(pyridin-2-yl)(4-(trifluoromethyl)phenyl)methanone (122377-19-9) + benzylamine (100-46-9) → 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine (1146973-47-8)

Guidance literature:

With copper(II) acetate monohydrate; In N,N-dimethyl-formamide; at 110 ℃; for 8h;

DOI:10.1021/jo5027723

Reference yield: 86.0%

phenylglycin (2835-06-5) + (pyridin-2-yl)(4-(trifluoromethyl)phenyl)methanone (122377-19-9) → 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine (1146973-47-8)

Guidance literature:

With di-tert-butyl peroxide; iodine; copper(II) bis(trifluoromethanesulfonate); In toluene; at 120 ℃; for 10h; Sealed tube;

DOI:10.1021/acs.joc.6b00343

Reference yield: 82.0%

1-(pyridin-2-yl)-1-(4-trifluoromethylphenyl)methylamine (1021417-83-3) + benzaldehyde (100-52-7) → 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine (1146973-47-8)

Guidance literature:

With sulfur; In dimethyl sulfoxide; at 20 - 80 ℃;

DOI:10.1021/jo900415y

upstream raw materials:

1-(pyridin-2-yl)-1-(4-trifluoromethylphenyl)methylamine

benzaldehyde

imidazo[1,5-a]pyridine

3-phenylimidazo[1,5-a]pyridine