(R)-1-(4-methoxy-benzyl)-7-oxo-azepane-2-carbaldehyde

Base Information

Chemical Name:(R)-1-(4-methoxy-benzyl)-7-oxo-azepane-2-carbaldehyde
CAS No.:1012322-66-5
Molecular Formula:C₁₅H₁₉NO₃
Molecular Weight:261.321
Hs Code.:

Synonyms:(R)-1-(4-methoxy-benzyl)-7-oxo-azepane-2-carbaldehyde

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Chemical Property of (R)-1-(4-methoxy-benzyl)-7-oxo-azepane-2-carbaldehyde

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Technology Process of (R)-1-(4-methoxy-benzyl)-7-oxo-azepane-2-carbaldehyde

There total 7 articles about (R)-1-(4-methoxy-benzyl)-7-oxo-azepane-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1012322-67-6
(R)-7-hydroxymethyl-1-(4-methoxy-benzyl)-azepan-2-one

: 1012322-66-5
(R)-1-(4-methoxy-benzyl)-7-oxo-azepane-2-carbaldehyde

Guidance literature:: With sodium hypochlorite; sodium hydrogencarbonate; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; potassium bromide; In water; ethyl acetate; toluene; for 3h;

Reference yield:

: 188195-09-7
(R)-2-[but-3-enoyl-(4-methoxy-benzyl)-amino]-pent-4-enoic acid methyl ester

: 1012322-66-5
(R)-1-(4-methoxy-benzyl)-7-oxo-azepane-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium / dichloromethane / 18 h / 50 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

3.1: lithium borohydride / tetrahydrofuran; dichloromethane / 18 h / 20 °C

3.2: pH 3

4.1: sodium hypochlorite; sodium hydrogencarbonate; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; potassium bromide / water; ethyl acetate; toluene / 3 h

With sodium hypochlorite; lithium borohydride; hydrogen; sodium hydrogencarbonate; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; potassium bromide; [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 188195-08-6
(R)-2-(4-methoxy-benzylamino)-pent-4-enoic acid methyl ester

: 1012322-66-5
(R)-1-(4-methoxy-benzyl)-7-oxo-azepane-2-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C

2.1: [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium / dichloromethane / 18 h / 50 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

4.1: lithium borohydride / tetrahydrofuran; dichloromethane / 18 h / 20 °C

4.2: pH 3

5.1: sodium hypochlorite; sodium hydrogencarbonate; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; potassium bromide / water; ethyl acetate; toluene / 3 h

With sodium hypochlorite; lithium borohydride; hydrogen; sodium hydrogencarbonate; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium bromide; [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene;