(R)-7-[2-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-1-(4-methoxy-benzyl)-azepan-2-one

Base Information

Chemical Name:(R)-7-[2-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-1-(4-methoxy-benzyl)-azepan-2-one
CAS No.:1012322-64-3
Molecular Formula:C₂₂H₂₅BrN₄O₂
Molecular Weight:457.37
Hs Code.:

Synonyms:

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Chemical Property of (R)-7-[2-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-1-(4-methoxy-benzyl)-azepan-2-one

Chemical Property:

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Technology Process of (R)-7-[2-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-1-(4-methoxy-benzyl)-azepan-2-one

There total 8 articles about (R)-7-[2-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-1-(4-methoxy-benzyl)-azepan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1012322-64-3
(R)-7-[2-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-1-(4-methoxy-benzyl)-azepan-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / diethyl ether; dichloromethane / 0.17 h / 20 °C

1.2: 18 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 1.5 h / 0 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C

4.1: [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium / dichloromethane / 18 h / 50 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

6.1: lithium borohydride / tetrahydrofuran; dichloromethane / 18 h / 20 °C

6.2: pH 3

7.1: sodium hypochlorite; sodium hydrogencarbonate; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; potassium bromide / water; ethyl acetate; toluene / 3 h

8.1: sodium hydride / tetrahydrofuran; 1,4-dioxane / 1 h / 40 °C

8.2: 48 h / 40 °C

9.1: hydrogen / platinum(IV) oxide / methanol / 24 h / 20 °C

With hydrogenchloride; sodium hypochlorite; sodium tetrahydroborate; lithium borohydride; hydrogen; sodium hydride; sodium hydrogencarbonate; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium bromide; platinum(IV) oxide; [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 188195-09-7
(R)-2-[but-3-enoyl-(4-methoxy-benzyl)-amino]-pent-4-enoic acid methyl ester

: 1012322-64-3
(R)-7-[2-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-1-(4-methoxy-benzyl)-azepan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium / dichloromethane / 18 h / 50 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

3.1: lithium borohydride / tetrahydrofuran; dichloromethane / 18 h / 20 °C

3.2: pH 3

4.1: sodium hypochlorite; sodium hydrogencarbonate; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; potassium bromide / water; ethyl acetate; toluene / 3 h

5.1: sodium hydride / tetrahydrofuran; 1,4-dioxane / 1 h / 40 °C

5.2: 48 h / 40 °C

6.1: hydrogen / platinum(IV) oxide / methanol / 24 h / 20 °C

With sodium hypochlorite; lithium borohydride; hydrogen; sodium hydride; sodium hydrogencarbonate; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; potassium bromide; platinum(IV) oxide; [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 1012322-66-5
(R)-1-(4-methoxy-benzyl)-7-oxo-azepane-2-carbaldehyde

: 1012322-64-3
(R)-7-[2-(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-1-(4-methoxy-benzyl)-azepan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; 1,4-dioxane / 1 h / 40 °C

1.2: 48 h / 40 °C

2.1: hydrogen / platinum(IV) oxide / methanol / 24 h / 20 °C

With hydrogen; sodium hydride; platinum(IV) oxide; In tetrahydrofuran; 1,4-dioxane; methanol;