4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylamine

Base Information

• Chemical Name: 4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylamine
• CAS No.: 1263384-55-9
• Molecular Formula: C₁₅H₂₁N₅O₂Si
• Molecular Weight: 331.45
• Mol file: 1263384-55-9.mol

Synonyms:4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylamine

Chemical Property of 4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylamine

There total 1 articles about 4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) + 3-amino-4-(1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazole (332026-86-5) → 4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylamine (1263384-55-9)

Guidance literature:

3-amino-4-(1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazole; With sodium hydride; In tetrahydrofuran; at 0 - 5 ℃; for 0.166667h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; at 0 - 5 ℃; for 0.5h;

Reference yield:

N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) + 4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylamine (1263384-55-9) → ({4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylcarbamoyl}methyl)carbamic acid benzyl ester (1263384-56-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 70 ℃; sealed tube;

Reference yield:

4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylamine (1263384-55-9) → 2-amino-N-(4-{1-[2-(4-amino-phenyl)-2-oxo-ethyl]-1H-benzoimidazol-2-yl}furazan3-yl)acetamide hydrochloride

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 70 °C / sealed tube

2.1: trifluoroacetic acid / 1 h / 20 °C

2.2: 1.5 h / 50 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / 1,4-dioxane; tetrahydrofuran; methanol / 7 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

upstream raw materials:

(2-trimethylethylsilylethoxy)methyl chloride

3-amino-4-(1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazole

Downstream raw materials:

({4-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]furazan-3-ylcarbamoyl}methyl)carbamic acid benzyl ester

{[4-(1H-benzoimidazol-2-yl)furazan-3-ylcarbamoyl]methyl}carbamic acid benzyl ester

[4-(2-{2-[4-(2-benzyloxycarbonylamino-acetylamino)furazan-3-yl]benzoimidazol-1-yl}acetyl)phenyl]carbamic acid benzyl ester