[4-(2-{2-[4-(2-benzyloxycarbonylamino-acetylamino)furazan-3-yl]benzoimidazol-1-yl}acetyl)phenyl]carbamic acid benzyl ester

Base Information

• Chemical Name: [4-(2-{2-[4-(2-benzyloxycarbonylamino-acetylamino)furazan-3-yl]benzoimidazol-1-yl}acetyl)phenyl]carbamic acid benzyl ester
• CAS No.: 1263384-58-2
• Molecular Formula: C₃₅H₂₉N₇O₇
• Molecular Weight: 659.658
• Mol file: 1263384-58-2.mol

Synonyms:[4-(2-{2-[4-(2-benzyloxycarbonylamino-acetylamino)furazan-3-yl]benzoimidazol-1-yl}acetyl)phenyl]carbamic acid benzyl ester

Chemical Property of [4-(2-{2-[4-(2-benzyloxycarbonylamino-acetylamino)furazan-3-yl]benzoimidazol-1-yl}acetyl)phenyl]carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(2-{2-[4-(2-benzyloxycarbonylamino-acetylamino)furazan-3-yl]benzoimidazol-1-yl}acetyl)phenyl]carbamic acid benzyl ester

There total 11 articles about [4-(2-{2-[4-(2-benzyloxycarbonylamino-acetylamino)furazan-3-yl]benzoimidazol-1-yl}acetyl)phenyl]carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-4-(1H-benzo[d]imidazol-2-yl)-1,2,5-oxadiazole (332026-86-5) → [4-(2-{2-[4-(2-benzyloxycarbonylamino-acetylamino)furazan-3-yl]benzoimidazol-1-yl}acetyl)phenyl]carbamic acid benzyl ester (1263384-58-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 - 5 °C

1.2: 0.5 h / 0 - 5 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 70 °C / sealed tube

3.1: trifluoroacetic acid / 1 h / 20 °C

3.2: 1.5 h / 50 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

{[4-(1H-benzoimidazol-2-yl)furazan-3-ylcarbamoyl]methyl}carbamic acid benzyl ester (1263384-57-1) + 4-((carbobenzyloxy)amino)phenacyl bromide (157014-41-0) → [4-(2-{2-[4-(2-benzyloxycarbonylamino-acetylamino)furazan-3-yl]benzoimidazol-1-yl}acetyl)phenyl]carbamic acid benzyl ester (1263384-58-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

2-(1H-benzo[d]imidazol-1-yl)acetonitrile (4414-74-8) → [4-(2-{2-[4-(2-benzyloxycarbonylamino-acetylamino)furazan-3-yl]benzoimidazol-1-yl}acetyl)phenyl]carbamic acid benzyl ester (1263384-58-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium nitrite; acetic acid / water / 20 °C / Cooling with ice

2.1: hydroxylamine hydrochloride; potassium hydroxide / diethylene glycol dimethyl ether / 170 °C / Cooling with ice

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 - 5 °C

3.2: 0.5 h / 0 - 5 °C

4.1: sodium hydride / tetrahydrofuran / 0 - 70 °C / sealed tube

5.1: trifluoroacetic acid / 1 h / 20 °C

5.2: 1.5 h / 50 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With hydroxylamine hydrochloride; sodium hydride; potassium carbonate; acetic acid; trifluoroacetic acid; potassium hydroxide; sodium nitrite; In tetrahydrofuran; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide;

upstream raw materials:

4-<<(benzyloxy)carbonyl>amino>acetophenone

N-(Benzyloxycarbonyl)glycine

2-(1H-benzo[d]imidazol-1-yl)acetonitrile

benzyl chloroformate