tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyanophenyl)ethyl]-D-alaninate

Base Information

Chemical Name:tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyanophenyl)ethyl]-D-alaninate
CAS No.:1355159-16-8
Molecular Formula:C₂₂H₃₆N₂O₃Si
Molecular Weight:404.625
Hs Code.:

Synonyms:tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyanophenyl)ethyl]-D-alaninate

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Chemical Property of tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyanophenyl)ethyl]-D-alaninate

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Technology Process of tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyanophenyl)ethyl]-D-alaninate

There total 4 articles about tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyanophenyl)ethyl]-D-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355159-15-7
N-[1-(4-cyanophenyl)-2-hydroxyethyl]-D-alanine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1355159-16-8
tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyanophenyl)ethyl]-D-alaninate

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 20099-89-2
4-Cyanophenacyl bromide

: 1355159-16-8
tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyanophenyl)ethyl]-D-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium formate / methanol / 15 h / 20 °C / Reflux

2.1: triethylamine / dichloromethane; methanol / 18 h / 20 - 70 °C

2.2: 1 h / 20 °C

3.1: 1H-imidazole / dichloromethane / 6 h / 20 °C

With 1H-imidazole; sodium formate; triethylamine; In methanol; dichloromethane;

Reference yield:

: 1443-80-7
4-cyanophenyl methyl ketone

: 1355159-16-8
tert-butyl N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-cyanophenyl)ethyl]-D-alaninate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene / acetonitrile; water / 18 h / Reflux

2.1: triethylamine / dichloromethane; methanol / 18 h / 20 - 70 °C

2.2: 1 h / 20 °C

3.1: 1H-imidazole / dichloromethane / 6 h / 20 °C

With 1H-imidazole; triethylamine; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In methanol; dichloromethane; water; acetonitrile;