(E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide

Base Information

Chemical Name:(E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide
CAS No.:1416977-96-2
Molecular Formula:C₂₃H₁₅Cl₂F₇N₂O₂
Molecular Weight:555.279
Hs Code.:

Synonyms:(E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide

Suppliers and Price of (E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide

There total 8 articles about (E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2516-99-6
3,3,3-Trifluoropropionic acid

: 1416980-12-5
(E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone

: 1416977-96-2
(E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 60.0%

: 2516-99-6
3,3,3-Trifluoropropionic acid

: (E)-2-amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl) ethanone

: 1416977-96-2
(E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide

Guidance literature:: In dichloromethane; ethyl acetate;

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1416977-96-2
(E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / triphenylphosphine; palladium dichloride / water; tetrahydrofuran / 16 h / Reflux; Inert atmosphere

2.1: dmap / acetonitrile / 3 h / 20 °C

3.1: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 2 h / 150 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.2: 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / potassium fluoride; 18-crown-6 ether / acetonitrile / 16 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 16 h / 20 °C

With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; [2,2]bipyridinyl; potassium fluoride; 18-crown-6 ether; triphenylphosphine; copper(l) chloride; palladium dichloride; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-benzene; acetonitrile;