(E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone

Base Information

Chemical Name:(E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone
CAS No.:1416980-12-5
Molecular Formula:C₂₀H₁₄Cl₂F₄N₂O
Molecular Weight:445.244
Hs Code.:

Synonyms:(E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone

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Chemical Property of (E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone

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Technology Process of (E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone

There total 5 articles about (E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10075-50-0
5-bromo-1H-indole

: 1416980-12-5
(E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / triphenylphosphine; palladium dichloride / water; tetrahydrofuran / 16 h / Reflux; Inert atmosphere

2.1: dmap / acetonitrile / 3 h / 20 °C

3.1: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 2 h / 150 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.2: 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / potassium fluoride; 18-crown-6 ether / acetonitrile / 16 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With dmap; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; [2,2]bipyridinyl; potassium fluoride; 18-crown-6 ether; triphenylphosphine; copper(l) chloride; palladium dichloride; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-benzene; acetonitrile;

Reference yield:

: 77132-99-1
5-ethenyl-1H-indole

: 1416980-12-5
(E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / acetonitrile / 3 h / 20 °C

2.1: [2,2]bipyridinyl; copper(l) chloride / 1,2-dichloro-benzene / 2 h / 150 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.2: 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / potassium fluoride; 18-crown-6 ether / acetonitrile / 16 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; [2,2]bipyridinyl; potassium fluoride; 18-crown-6 ether; copper(l) chloride; In dichloromethane; 1,2-dichloro-benzene; acetonitrile;

Reference yield:

: 1416980-09-0
(E)-tert-Butyl 5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indole-1-carboxylate

: 1416980-12-5
(E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / potassium fluoride; 18-crown-6 ether / acetonitrile / 16 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium fluoride; 18-crown-6 ether; In dichloromethane; acetonitrile;