(4-bromophenyl)(3-(4-chlorophenyl)oxiran-2-yl)methanone

Base Information

• Chemical Name: (4-bromophenyl)(3-(4-chlorophenyl)oxiran-2-yl)methanone
• CAS No.: 27547-11-1
• Molecular Formula: C₁₅H₁₀BrClO₂
• Molecular Weight: 337.6
• Mol file: 27547-11-1.mol

Synonyms:(4-bromophenyl)(3-(4-chlorophenyl)oxiran-2-yl)methanone

Chemical Property of (4-bromophenyl)(3-(4-chlorophenyl)oxiran-2-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-bromophenyl)(3-(4-chlorophenyl)oxiran-2-yl)methanone

There total 8 articles about (4-bromophenyl)(3-(4-chlorophenyl)oxiran-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(4-bromophenyl)-3-(4-chlorophenyl)prop-2-en-1-one (6332-22-5) → trans-(2R,3S)-epoxy-1-(4-bromophenyl)-3-(4-chlorophenyl) propan-1-one (27547-11-1,32157-72-5)

Guidance literature:

With C₅₈H₆₄N₄O₄S⁽²⁺⁾*2Br^(1-); dihydrogen peroxide; caesium carbonate; In water; toluene; at 20 ℃; for 4.5h; Reagent/catalyst; enantioselective reaction;

DOI:10.1016/j.molcata.2015.08.016

Reference yield: 96.0%

1-(4-bromophenyl)-2-chloroethan-1-one (4209-02-3) + 4-chlorobenzaldehyde (104-88-1) → (4-bromophenyl)(3-(4-chlorophenyl)oxiran-2-yl)methanone (27547-11-1)

Guidance literature:

1-(4-bromophenyl)-2-chloroethan-1-one; With C₃₁H₃₈N₂O₈; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

4-chlorobenzaldehyde; In tetrahydrofuran; at 0 ℃; for 24h; enantioselective reaction;

DOI:10.1039/c7cc06194c

Reference yield: 91.0%

1-(4-bromophenyl)-3-(4-chlorophenyl)prop-2-en-1-one (6332-22-5) → (4-bromophenyl)(3-(4-chlorophenyl)oxiran-2-yl)methanone (27547-11-1)

Guidance literature:

With Amberlyst A-26 (OH^- form); dihydrogen peroxide; In 1,4-dioxane; at 20 ℃; for 6h;

DOI:10.1081/SCC-100104010

upstream raw materials:

1-(4-bromophenyl)-3-(4-chlorophenyl)prop-2-en-1-one

4-chlorobenzaldehyde

para-bromoacetophenone

1-(4-bromophenyl)-2-chloroethan-1-one

Downstream raw materials:

1-(4-bromophenyl)-2-(4-chlorophenyl)ethanone

Refernces

• 1、 -. "epoxy Zha Tong and a method for its synthesis of derivatives". Paragraph 0057; 0058; 0059. . Retrieved 2016/10/20.
• 2、 Ngo, Dalyna,Kalala, Mbelu,Hogan, Victoria,Manchanayakage, Renuka. "One-pot synthesis of chalcone epoxides - A green chemistry strategy". . p. 4496 - 4500. Retrieved 2014/08/05.