5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

Base Information

• Chemical Name: 5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl
• CAS No.: 1093217-92-5
• Molecular Formula: C₁₃H₁₉BrN₂
• Molecular Weight: 283.211
• Mol file: 1093217-92-5.mol

Synonyms:5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

Chemical Property of 5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

There total 1 articles about 5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-bromo-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl (845788-60-5) + acetone (67-64-1) → 5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl (1093217-92-5)

Guidance literature:

5-bromo-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl; acetone; With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃;

With hydrogenchloride; In methanol; water;

In dichloromethane; water; pH=12;

Reference yield: 58.0%

5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl (1093217-92-5) + 4-(N,N-dimethylaminocarbonyl)phenylboronic acid (405520-68-5) → 4-(1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-5-yl)-N,N-dimethylbenzamide dihydrochloride

Guidance literature:

5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl; 4-(N,N-dimethylaminocarbonyl)phenylboronic acid; With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 85 ℃; for 0.333333h; microwave;

With hydrogenchloride; In methanol; diethyl ether;

Reference yield: 58.0%

5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl (1093217-92-5) + 3-fluoro-4-(pyrrolidine-1-carbonyl)phenylboronic acid (874289-09-5) → [2-fluoro-4-(1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl-5-yl)phenyl]pyrrolidin-1-ylmethanone dihydrochloride

Guidance literature:

5-bromo-1'-isopropyl-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl; 3-fluoro-4-(pyrrolidine-1-carbonyl)phenylboronic acid; With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 85 ℃; for 0.416667h; microwave;

With hydrogenchloride; In water; acetonitrile;

upstream raw materials:

5-bromo-1',2',3',4',5',6'-hexahydro-[2,4']bipyridinyl

acetone