(R)-tert-butyl 4-(2-amino-4-(methoxycarbonyl)-5-(methylsulfonyl)phenyl)-2-isopropyl-3-oxopiperazine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4-(2-amino-4-(methoxycarbonyl)-5-(methylsulfonyl)phenyl)-2-isopropyl-3-oxopiperazine-1-carboxylate
CAS No.:1456693-07-4
Molecular Formula:C₂₁H₃₁N₃O₇S
Molecular Weight:469.559
Hs Code.:

Synonyms:(R)-tert-butyl 4-(2-amino-4-(methoxycarbonyl)-5-(methylsulfonyl)phenyl)-2-isopropyl-3-oxopiperazine-1-carboxylate

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Chemical Property of (R)-tert-butyl 4-(2-amino-4-(methoxycarbonyl)-5-(methylsulfonyl)phenyl)-2-isopropyl-3-oxopiperazine-1-carboxylate

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Technology Process of (R)-tert-butyl 4-(2-amino-4-(methoxycarbonyl)-5-(methylsulfonyl)phenyl)-2-isopropyl-3-oxopiperazine-1-carboxylate

There total 9 articles about (R)-tert-butyl 4-(2-amino-4-(methoxycarbonyl)-5-(methylsulfonyl)phenyl)-2-isopropyl-3-oxopiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1456693-06-3
(R)-tert-butyl 2-isopropyl-4-(4-(methoxycarbonyl)-5-(methylsulfonyl)-2-nitrophenyl)-3-oxopiperazine-1-carboxylate

: 1456693-07-4
(R)-tert-butyl 4-(2-amino-4-(methoxycarbonyl)-5-(methylsulfonyl)phenyl)-2-isopropyl-3-oxopiperazine-1-carboxylate

Guidance literature:: With hydrogen; In tetrahydrofuran; methanol; water; at 20 ℃; under 1551.49 Torr;

Reference yield:

: 1456693-02-9
(R)-benzyl 2-isopropyl-3-oxopiperazine-1-carboxylate

: 1456693-07-4
(R)-tert-butyl 4-(2-amino-4-(methoxycarbonyl)-5-(methylsulfonyl)phenyl)-2-isopropyl-3-oxopiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 15% palladium on carbon; hydrogen / methanol / 20 °C

2.1: 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -10 °C / Inert atmosphere

3.2: 0.33 h / -30 - -20 °C

4.1: 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

6.1: hydrogen / tetrahydrofuran; methanol; water / 20 °C / 1551.49 Torr

With 15% palladium on carbon; hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1456693-00-7
(R)-benzyl (1-((2,2-dimethoxyethyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

: 1456693-07-4
(R)-tert-butyl 4-(2-amino-4-(methoxycarbonyl)-5-(methylsulfonyl)phenyl)-2-isopropyl-3-oxopiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: trifluoroacetic acid / 12 h / 20 °C

2.1: triethylsilane / 1,2-dichloro-ethane / 36 h / 20 °C / Reflux

3.1: 15% palladium on carbon; hydrogen / methanol / 20 °C

4.1: 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -10 °C / Inert atmosphere

5.2: 0.33 h / -30 - -20 °C

6.1: 1 h / 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

8.1: hydrogen / tetrahydrofuran; methanol; water / 20 °C / 1551.49 Torr

With triethylsilane; 15% palladium on carbon; hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;