(R)-methyl 1-isopropyl-7-(methylsulfonyl)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine-8-carboxylate

Base Information

Chemical Name:(R)-methyl 1-isopropyl-7-(methylsulfonyl)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine-8-carboxylate
CAS No.:1456704-59-8
Molecular Formula:C₂₁H₂₂F₃N₅O₄S
Molecular Weight:497.498
Hs Code.:
Mol file:1456704-59-8.mol

(R)-methyl 1-isopropyl-7-(methylsulfonyl)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine-8-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 1-isopropyl-7-(methylsulfonyl)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine-8-carboxylate

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (R)-methyl 1-isopropyl-7-(methylsulfonyl)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine-8-carboxylate

There total 12 articles about (R)-methyl 1-isopropyl-7-(methylsulfonyl)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1456693-55-2
(R)-methyl 1-isopropyl-7-(methylsulfonyl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo [1,2-a]pyrazine-8-carboxylate

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1456704-59-8
(R)-methyl 1-isopropyl-7-(methylsulfonyl)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine-8-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 150 ℃; for 2h; Microwave irradiation;

Reference yield:

: 1685-33-2
N-[(benzyloxy)carbonyl]-D-valine

: 1456704-59-8
(R)-methyl 1-isopropyl-7-(methylsulfonyl)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine-8-carboxylate

Guidance literature:: Multi-step reaction with 12 steps

1.1: 4-methyl-morpholine; isobutyl chlorocarbonate / tetrahydrofuran / 0.5 h / -15 °C

1.2: 2 h / -15 °C

2.1: trifluoroacetic acid / 12 h / 20 °C

3.1: triethylsilane / 1,2-dichloro-ethane / 36 h / 20 °C / Reflux

4.1: 15% palladium on carbon; hydrogen / methanol / 20 °C

5.1: 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -10 °C / Inert atmosphere

6.2: 0.33 h / -30 - -20 °C

7.1: 1 h / 20 °C

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

9.1: hydrogen / tetrahydrofuran; methanol; water / 20 °C / 1551.49 Torr

10.1: tin(IV) chloride; triethylamine / dichloromethane / 20 °C

11.1: trifluoroacetic acid / dichloromethane / 3.03 h / 20 °C

12.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 150 °C / Microwave irradiation

With 4-methyl-morpholine; triethylsilane; 15% palladium on carbon; hydrogen; tin(IV) chloride; sodium hydride; isobutyl chlorocarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 1456693-00-7
(R)-benzyl (1-((2,2-dimethoxyethyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

: 1456704-59-8
(R)-methyl 1-isopropyl-7-(methylsulfonyl)-2-(4-(trifluoromethyl)pyrimidin-2-yl)-1,2,3,4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrazine-8-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: trifluoroacetic acid / 12 h / 20 °C

2.1: triethylsilane / 1,2-dichloro-ethane / 36 h / 20 °C / Reflux

3.1: 15% palladium on carbon; hydrogen / methanol / 20 °C

4.1: 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / -10 °C / Inert atmosphere

5.2: 0.33 h / -30 - -20 °C

6.1: 1 h / 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

8.1: hydrogen / tetrahydrofuran; methanol; water / 20 °C / 1551.49 Torr

9.1: tin(IV) chloride; triethylamine / dichloromethane / 20 °C

10.1: trifluoroacetic acid / dichloromethane / 3.03 h / 20 °C

11.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 150 °C / Microwave irradiation

With triethylsilane; 15% palladium on carbon; hydrogen; tin(IV) chloride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;