1-<3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuranosyl>-4-carbamoyl-5-<(N-benzoylthiocarbamoyl)amino>imidazole

Base Information

Chemical Name:1-<3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuranosyl>-4-carbamoyl-5-<(N-benzoylthiocarbamoyl)amino>imidazole
CAS No.:99355-42-7
Molecular Formula:C₃₀H₄₉N₅O₆SSi₂
Molecular Weight:663.986
Hs Code.:

Synonyms:1-<3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuranosyl>-4-carbamoyl-5-<(N-benzoylthiocarbamoyl)amino>imidazole

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Chemical Property of 1-<3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuranosyl>-4-carbamoyl-5-<(N-benzoylthiocarbamoyl)amino>imidazole

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Technology Process of 1-<3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuranosyl>-4-carbamoyl-5-<(N-benzoylthiocarbamoyl)amino>imidazole

There total 6 articles about 1-<3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuranosyl>-4-carbamoyl-5-<(N-benzoylthiocarbamoyl)amino>imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 99355-41-6
1-<3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuranosyl>-4-carbamoyl-5-<(N-benzoylthiocarbamoyl)amino>imidazole

: 74-88-4
methyl iodide

: 99355-42-7
1-<3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuranosyl>-4-carbamoyl-5-<(N-benzoylthiocarbamoyl)amino>imidazole

Guidance literature:: With sodium methylate; In methanol; for 2h; Ambient temperature;
DOI:10.1021/jm00152a007

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 99355-42-7
1-<3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuranosyl>-4-carbamoyl-5-<(N-benzoylthiocarbamoyl)amino>imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / imidazole / dimethylformamide / 3 h

2: Raney nickel / dioxane / 0.75 h / Heating

3: 40 percent / methanol / 1 h / Heating

4: 67 percent / acetone / 1 h / Heating

5: 81 percent / sodium methoxide / methanol / 2 h / Ambient temperature

With 1H-imidazole; sodium methylate; nickel; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00152a007

Reference yield:

: 99436-43-8
3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuran<1',2':4,5>-2-oxazoline

: 99355-42-7
1-<3',5'-bis-O-(tert-butyldimethylsilyl)-α-D-xylofuranosyl>-4-carbamoyl-5-<(N-benzoylthiocarbamoyl)amino>imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / methanol / 1 h / Heating

2: 67 percent / acetone / 1 h / Heating

3: 81 percent / sodium methoxide / methanol / 2 h / Ambient temperature

With sodium methylate; In methanol; acetone;
DOI:10.1021/jm00152a007