3-(allyl(methyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

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Chemical Name:3-(allyl(methyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide
CAS No.:1355994-12-5
Molecular Formula:C₁₈H₂₄N₄O₃
Molecular Weight:344.414
Hs Code.:

Synonyms:3-(allyl(methyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

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Chemical Property of 3-(allyl(methyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

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Technology Process of 3-(allyl(methyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

There total 6 articles about 3-(allyl(methyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1355994-11-4
N-methoxy-1-(4-methoxybenzyl)-N-methyl-3-(methylamino)-1H-pyrazole-4-carboxamide

: 106-95-6
allyl bromide

: 1355994-12-5
3-(allyl(methyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: N-methoxy-1-(4-methoxybenzyl)-N-methyl-3-(methylamino)-1H-pyrazole-4-carboxamide; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 45 ℃; for 20h;

allyl bromide; at 65 ℃; for 2h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1355994-12-5
3-(allyl(methyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 4 h / Reflux

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 60 °C

2.2: pH 1 - 2

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

3.2: 1 h / 0 - 20 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

4.2: 1.08 h / -78 - 20 °C

5.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 140 °C / Microwave irradiation

6.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 45 °C

6.2: 2 h / 65 °C

With oxalyl dichloride; water; sodium hydride; potassium carbonate; N,N-dimethyl-formamide; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1105039-93-7
1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylic acid

: 1355994-12-5
3-(allyl(methyl)amino)-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

2.2: 1.08 h / -78 - 20 °C

3.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 140 °C / Microwave irradiation

4.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 45 °C

4.2: 2 h / 65 °C

With oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;