1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-((trifluoromethyl)thio)ethanone

Base Information

Chemical Name:1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-((trifluoromethyl)thio)ethanone
CAS No.:1398608-94-0
Molecular Formula:C₂₃H₁₅Cl₂F₇N₂O₃S
Molecular Weight:603.345
Hs Code.:

1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-((trifluoromethyl)thio)ethanone

Synonyms:1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-((trifluoromethyl)thio)ethanone

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Chemical Property of 1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-((trifluoromethyl)thio)ethanone

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Technology Process of 1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-((trifluoromethyl)thio)ethanone

There total 5 articles about 1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-((trifluoromethyl)thio)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2408-17-5
[(trifluoromethyl)sulfanyl]acetic acid

: 1398609-72-7
5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

: 1398608-94-0
1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-((trifluoromethyl)thio)ethanone

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1398609-70-5
1-benzhydryl-3-(2-hydroxymethyl-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

: 1398608-94-0
1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-((trifluoromethyl)thio)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; p-toluenesulfonylanhydride / toluene / 16 h / 0 - 20 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2 h / 75 °C

2.2: 1 h / Reflux

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; p-toluenesulfonylanhydride; triethylamine; HATU; In N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1398609-69-2
1-benzhydryl-5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-3'-one

: 1398608-94-0
1-(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-((trifluoromethyl)thio)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride / tetrahydrofuran / 16 h / 20 °C

2.1: triethylamine; p-toluenesulfonylanhydride / toluene / 16 h / 0 - 20 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2 h / 75 °C

3.2: 1 h / Reflux

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With lithium borohydride; carbonochloridic acid 1-chloro-ethyl ester; p-toluenesulfonylanhydride; triethylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;