4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester

Base Information

Chemical Name:4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester
CAS No.:868355-42-4
Molecular Formula:C₂₈H₂₇ClF₃N₅O₅
Molecular Weight:606.001
Hs Code.:

4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester

Synonyms:4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester

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Chemical Property of 4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester

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Technology Process of 4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester

There total 1 articles about 4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 205059-12-7
1,3-dihydro-3-(4-piperidinyl)-imidazo[4,5-c]quinolin-2(2H)-one

: 868355-43-5
(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester

: 7693-46-1
4-Nitrophenyl chloroformate

: 868355-42-4
4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester

Guidance literature:: 4-Nitrophenyl chloroformate; With dmap; In pyridine; at 20 ℃; for 1h;

(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester; In pyridine; at 20 ℃; for 2h;

1,3-dihydro-3-(4-piperidinyl)-imidazo[4,5-c]quinolin-2(2H)-one; In pyridine; at 20 ℃; for 48h;

Reference yield: 77.0%

: 868355-42-4
4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester

: 868355-44-6
4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-carboxy-ethylester

Guidance literature:: 4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 3h;

With hydrogenchloride; In water;