5-((4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)methyl)-3-(trifluoromethyl)-1,2,4-oxadiazole

Base Information

Chemical Name:5-((4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)methyl)-3-(trifluoromethyl)-1,2,4-oxadiazole
CAS No.:1287685-44-2
Molecular Formula:C₂₁H₂₅F₅N₄O₄S
Molecular Weight:524.512
Hs Code.:

Synonyms:5-((4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)methyl)-3-(trifluoromethyl)-1,2,4-oxadiazole

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Chemical Property of 5-((4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)methyl)-3-(trifluoromethyl)-1,2,4-oxadiazole

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Technology Process of 5-((4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)methyl)-3-(trifluoromethyl)-1,2,4-oxadiazole

There total 6 articles about 5-((4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)methyl)-3-(trifluoromethyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287686-12-7
4-(3,5-difluoro-4-(piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine trifluoroacetate

: 100442-49-7
5-(chloromethyl)-3-(trifluoro-methyl)-1,2,4-oxadiazole

: 1287685-44-2
5-((4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)methyl)-3-(trifluoromethyl)-1,2,4-oxadiazole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 3h;

Reference yield:

: 1287686-22-9
methyl 2-(4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)acetate

: 4314-35-6
2,2,2-trifluoro-N'-hydroxyacetimidamide

: 1287685-44-2
5-((4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)methyl)-3-(trifluoromethyl)-1,2,4-oxadiazole

Guidance literature:: 2,2,2-trifluoro-N'-hydroxyacetimidamide; With sodium hydride; In 1,4-dioxane; mineral oil; at 60 ℃; for 1h;

methyl 2-(4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)acetate; In 1,4-dioxane; mineral oil; at 100 ℃; Molecular sieve;

Reference yield:

: 104197-14-0
5-bromo-1,3-difluoro-2-methoxy-benzene

: 1287685-44-2
5-((4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidin-1-yl)methyl)-3-(trifluoromethyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation; Sealed tube

2.1: hydrogen; trifluoroacetic acid; acetic acid / platinum(IV) oxide / 7 h

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 23 °C

4.1: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C

5.1: potassium tert-butylate / dimethyl sulfoxide / 0.33 h / 20 °C

5.2: 15 h / 100 °C

6.1: dichloromethane / 15 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 60 °C

With potassium tert-butylate; hydrogen; boron tribromide; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;