4-(3,5-difluoro-4-(piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine trifluoroacetate

Base Information

Chemical Name:4-(3,5-difluoro-4-(piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine trifluoroacetate
CAS No.:1287686-12-7
Molecular Formula:C₂HF₃O₂*C₁₇H₂₄F₂N₂O₃S
Molecular Weight:488.476
Hs Code.:

Synonyms:4-(3,5-difluoro-4-(piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine trifluoroacetate

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Chemical Property of 4-(3,5-difluoro-4-(piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine trifluoroacetate

Chemical Property:

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Technology Process of 4-(3,5-difluoro-4-(piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine trifluoroacetate

There total 7 articles about 4-(3,5-difluoro-4-(piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287686-09-2
tert-butyl 4-(2,6-difluoro-4-(1-(methylsulfonyl)piperidin-4-yl)phenoxy)piperidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1287686-12-7
4-(3,5-difluoro-4-(piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 15h;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1287686-12-7
4-(3,5-difluoro-4-(piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation; Sealed tube

2.1: hydrogen; trifluoroacetic acid; acetic acid / platinum(IV) oxide / 7 h

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 23 °C

4.1: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C

5.1: potassium tert-butylate / dimethyl sulfoxide / 0.33 h / 20 °C

5.2: 15 h / 100 °C

6.1: dichloromethane / 15 h / 20 °C

With potassium tert-butylate; hydrogen; boron tribromide; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 104197-14-0
5-bromo-1,3-difluoro-2-methoxy-benzene

: 1287686-12-7
4-(3,5-difluoro-4-(piperidin-4-yloxy)phenyl)-1-(methylsulfonyl)piperidine trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.25 h / 150 °C / Microwave irradiation; Sealed tube

2.1: hydrogen; trifluoroacetic acid; acetic acid / platinum(IV) oxide / 7 h

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 23 °C

4.1: boron tribromide / dichloromethane / 1.5 h / 0 - 20 °C

5.1: potassium tert-butylate / dimethyl sulfoxide / 0.33 h / 20 °C

5.2: 15 h / 100 °C

6.1: dichloromethane / 15 h / 20 °C

With potassium tert-butylate; hydrogen; boron tribromide; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;