benzyl 4-(2-((S)-N-((S)-2,6-dioxo-1-phenethylpiperidin-3-yl)-2-methylbutanamido)acetamido)butanoate

Base Information

Chemical Name:benzyl 4-(2-((S)-N-((S)-2,6-dioxo-1-phenethylpiperidin-3-yl)-2-methylbutanamido)acetamido)butanoate
CAS No.:1356018-26-2
Molecular Formula:C₃₁H₃₉N₃O₆
Molecular Weight:549.667
Hs Code.:

Synonyms:benzyl 4-(2-((S)-N-((S)-2,6-dioxo-1-phenethylpiperidin-3-yl)-2-methylbutanamido)acetamido)butanoate

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Chemical Property of benzyl 4-(2-((S)-N-((S)-2,6-dioxo-1-phenethylpiperidin-3-yl)-2-methylbutanamido)acetamido)butanoate

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Technology Process of benzyl 4-(2-((S)-N-((S)-2,6-dioxo-1-phenethylpiperidin-3-yl)-2-methylbutanamido)acetamido)butanoate

There total 7 articles about benzyl 4-(2-((S)-N-((S)-2,6-dioxo-1-phenethylpiperidin-3-yl)-2-methylbutanamido)acetamido)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1730-91-2
(S)-2-Methylbutyric acid

: 1175950-31-8
C₁₃H₁₆N₂O₂

: 1345855-73-3
benzyl 4-isocyanobutanoate

: 1356018-26-2
benzyl 4-(2-((S)-N-((S)-2,6-dioxo-1-phenethylpiperidin-3-yl)-2-methylbutanamido)acetamido)butanoate

Guidance literature:: formaldehyd; C₁₃H₁₆N₂O₂; In methanol; at 20 ℃; for 2h;

(S)-2-Methylbutyric acid; benzyl 4-isocyanobutanoate; In methanol; at 20 ℃; for 18h;
DOI:10.3762/bjoc.7.175

Reference yield:

: 2650-64-8
Cbz-L-Gln

: 1356018-26-2
benzyl 4-(2-((S)-N-((S)-2,6-dioxo-1-phenethylpiperidin-3-yl)-2-methylbutanamido)acetamido)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 18 h / 80 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

4.1: methanol / 2 h / 20 °C

4.2: 18 h / 20 °C

With 1-hydroxy-pyrrolidine-2,5-dione; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction / 4.1: Ugi reaction / 4.2: Ugi reaction;
DOI:10.3762/bjoc.7.175

Reference yield:

: 1356018-30-8
benzyl 4-formamidobutanoate

: 1356018-26-2
benzyl 4-(2-((S)-N-((S)-2,6-dioxo-1-phenethylpiperidin-3-yl)-2-methylbutanamido)acetamido)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; trichlorophosphate / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: methanol / 2 h / 20 °C

2.2: 18 h / 20 °C

With diisopropylamine; trichlorophosphate; In methanol; dichloromethane; 2.1: Ugi reaction / 2.2: Ugi reaction;
DOI:10.3762/bjoc.7.175