benzyl 3,3-bis-(hydroxymethyl)-1,5-dioxa-9-azaspiro[5.5]undecane-9-carboxylate

Base Information

Chemical Name:benzyl 3,3-bis-(hydroxymethyl)-1,5-dioxa-9-azaspiro[5.5]undecane-9-carboxylate
CAS No.:945843-07-2
Molecular Formula:C₁₈H₂₅NO₆
Molecular Weight:351.4
Hs Code.:

Synonyms:benzyl 3,3-bis-(hydroxymethyl)-1,5-dioxa-9-azaspiro[5.5]undecane-9-carboxylate

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Chemical Property of benzyl 3,3-bis-(hydroxymethyl)-1,5-dioxa-9-azaspiro[5.5]undecane-9-carboxylate

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Technology Process of benzyl 3,3-bis-(hydroxymethyl)-1,5-dioxa-9-azaspiro[5.5]undecane-9-carboxylate

There total 4 articles about benzyl 3,3-bis-(hydroxymethyl)-1,5-dioxa-9-azaspiro[5.5]undecane-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 115-77-5
Pentaerythritol

: 945843-07-2
benzyl 3,3-bis-(hydroxymethyl)-1,5-dioxa-9-azaspiro[5.5]undecane-9-carboxylate

Guidance literature:: toluene-4-sulfonic acid; In N,N-dimethyl-formamide; benzene; for 2h; Heating;
DOI:10.1002/chem.200700108

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 945843-07-2
benzyl 3,3-bis-(hydroxymethyl)-1,5-dioxa-9-azaspiro[5.5]undecane-9-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 20 °C

2: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

3: 58 percent / p-toluenesulfonic acid / dimethylformamide; benzene / 2 h / Heating

With Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide; benzene; 2: Dess-Martin oxidation;
DOI:10.1002/chem.200700108

Reference yield:

: 95798-23-5
1-(benzyloxycarbonyl)-4-hydroxypiperidine

: 945843-07-2
benzyl 3,3-bis-(hydroxymethyl)-1,5-dioxa-9-azaspiro[5.5]undecane-9-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

2: 58 percent / p-toluenesulfonic acid / dimethylformamide; benzene / 2 h / Heating

With Dess-Martin periodane; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide; benzene; 1: Dess-Martin oxidation;
DOI:10.1002/chem.200700108