N-(2-iodo-allyl)-4-methyl-N-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide

Base Information

Chemical Name:N-(2-iodo-allyl)-4-methyl-N-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide
CAS No.:823787-96-8
Molecular Formula:C₁₇H₂₀INO₃S
Molecular Weight:445.321
Hs Code.:

<i>N</i>-(2-iodo-allyl)-4-methyl-<i>N</i>-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide

Synonyms:N-(2-iodo-allyl)-4-methyl-N-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide

Suppliers and Price of N-(2-iodo-allyl)-4-methyl-N-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-iodo-allyl)-4-methyl-N-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide

Chemical Property:

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Technology Process of N-(2-iodo-allyl)-4-methyl-N-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide

There total 7 articles about N-(2-iodo-allyl)-4-methyl-N-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 654065-37-9
2-iodo-2-propenyl-4-methylbenzenesulfonate

: 823787-93-5
4-methyl-N-{[(1R,5S)-5-methyl-4-oxo-2-cyclopenten-1-yl]methyl}benzenesulfonamide

: 823787-96-8
N-(2-iodo-allyl)-4-methyl-N-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide

Guidance literature:: With potassium carbonate; In acetonitrile; Heating;
DOI:10.1021/ja0401702

Reference yield:

: 56745-67-6,61305-35-9,61740-33-8,61305-36-0
(4S)-4-tert-butyldimethylsilyloxycyclopent-2-en-1-one

: 823787-96-8
N-(2-iodo-allyl)-4-methyl-N-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: butyllithium; dimethylzinc / tetrahydrofuran; hexane / 0.25 h / 0 °C

1.2: tetrahydrofuran; hexane / 0.25 h / -78 °C

1.3: 77 percent / hexamethylphosphoramide / tetrahydrofuran; hexane / 16 h / -40 °C

2.1: ozone / CH₂Cl₂; methanol / -78 °C

2.2: 96 percent / methyl sulfide / CH₂Cl₂; methanol / 2 h / 20 °C

3.1: 71 percent / sodium borohydride / tetrahydrofuran; ethanol / 0.5 h

4.1: 99 percent / triphenylphosphine; diethyl azidocarboxylate / tetrahydrofuran / 1 h / 20 °C

5.1: 95 percent / trifluoroacetic acid / CH₂Cl₂ / 16 h / 20 °C

6.1: 80 percent / K₂CO₃ / acetonitrile / Heating

With sodium tetrahydroborate; n-butyllithium; dimethyl zinc(II); potassium carbonate; ozone; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; acetonitrile; 4.1: Mitsunobu reaction;
DOI:10.1021/ja0401702

Reference yield:

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

: 823787-96-8
N-(2-iodo-allyl)-4-methyl-N-(5-methyl-4-oxo-cyclopent-2-enylmethyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / triphenylphosphine; diethyl azidocarboxylate / tetrahydrofuran / 1 h / 20 °C

2: 95 percent / trifluoroacetic acid / CH₂Cl₂ / 16 h / 20 °C

3: 80 percent / K₂CO₃ / acetonitrile / Heating

With potassium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1021/ja0401702