1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methyl-N-propargylamino)-2-propanol

Base Information

• Chemical Name: 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methyl-N-propargylamino)-2-propanol
• CAS No.: 1448798-63-7
• Molecular Formula: C₁₅H₁₆F₂N₄O
• Molecular Weight: 306.315
• Mol file: 1448798-63-7.mol

Synonyms:1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methyl-N-propargylamino)-2-propanol

Chemical Property of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methyl-N-propargylamino)-2-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methyl-N-propargylamino)-2-propanol

There total 6 articles about 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methyl-N-propargylamino)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methylamino)-2-propanol (261959-40-4) + propargyl bromide (106-96-7) → 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methyl-N-propargylamino)-2-propanol (1448798-63-7)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; at 20 ℃; for 6h;

DOI:10.1039/c3md20086h

Reference yield:

1,3-Difluorobenzene (372-18-9) → 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methyl-N-propargylamino)-2-propanol (1448798-63-7)

Guidance literature:

Multi-step reaction with 6 steps

1: aluminum (III) chloride / 5 h / 50 °C

2: sodium hydrogencarbonate / toluene / 5 h / Reflux

3: sodium hydroxide / toluene / 3 h / 60 °C

4: methanesulfonic acid / 1 h / 0 °C

5: triethylamine / methanol / 6 h / Reflux

6: potassium iodide; potassium carbonate / acetonitrile / 6 h / 20 °C

With aluminum (III) chloride; methanesulfonic acid; sodium hydrogencarbonate; potassium carbonate; triethylamine; potassium iodide; sodium hydroxide; In methanol; toluene; acetonitrile;

DOI:10.1039/c3md20086h

Reference yield:

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate (86386-77-8) → 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methyl-N-propargylamino)-2-propanol (1448798-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / methanol / 6 h / Reflux

2: potassium iodide; potassium carbonate / acetonitrile / 6 h / 20 °C

With potassium carbonate; triethylamine; potassium iodide; In methanol; acetonitrile;

DOI:10.1039/c3md20086h

upstream raw materials:

1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difuorophenyl)-3-(N-methylamino)-2-propanol

propargyl bromide

1,3-Difluorobenzene

Downstream raw materials:

C₂₂H₂₂F₃N₇O

C₂₂H₂₂F₃N₇O

C₂₂H₂₂ClF₂N₇O

C₂₂H₂₂ClF₂N₇O