1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone

Base Information

• Chemical Name: 1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone
• CAS No.: 115156-70-2
• Molecular Formula: C₂₀H₂₉NO₂
• Molecular Weight: 315.456
• Mol file: 115156-70-2.mol

Synonyms:1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone

Chemical Property of 1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone

There total 5 articles about 1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-((2S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-2-methanesulfinyl-ethanone (115156-69-9) → 1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone (115156-70-2)

Guidance literature:

With aluminium amalgam; In tetrahydrofuran; water; for 1.5h; Yield given; Heating;

DOI:10.1021/jo00294a026

Reference yield:

(4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazine-2-carboxylic acid methyl ester (115156-68-8,125353-88-0,125353-89-1) → 1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone (115156-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; paraffin / 1 h / Ambient temperature

2: aluminum amalgam / tetrahydrofuran; H₂O / 1.5 h / Heating

With aluminium amalgam; In tetrahydrofuran; water; paraffin;

DOI:10.1021/jo00294a026

Reference yield:

(1R,2S,5R)-5-methyl-2-<1-methyl-1-(benzylamino)ethyl>cyclohexan-1-ol (115156-56-4) → 1-<<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazin-2-yl>ethanone (115156-70-2)

Guidance literature:

Multi-step reaction with 3 steps

3: Al/Hg

With aluminum amalgam;

DOI:10.1016/S0040-4020(01)87677-8

upstream raw materials:

1-((2S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-2-methanesulfinyl-ethanone

(4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazine-2-carboxylic acid methyl ester

methyl iodide

(1R,2S,5R)-5-methyl-2-<1-methyl-1-(benzylamino)ethyl>cyclohexan-1-ol

Downstream raw materials:

α-methyl-<2S(2α,4aα,7α,8aβ)>-octahydro-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol

(R)-1-((2S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-ethanol

α-methyl-<2S(2α,4aα,7α,8aβ)>-octahydro-α-phenyl-3-(phenylmethyl)-4,4,7-trimethyl-2H-1,3-benzoxazine-2-methanol

(S)-1-((2S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-1-phenyl-ethanol