trans-(2R,3S)-epoxy-3-(3-nitrophenyl)-1-phenyl-1-propan-1-one

Base Information

• Chemical Name: trans-(2R,3S)-epoxy-3-(3-nitrophenyl)-1-phenyl-1-propan-1-one
• CAS No.: 128672-45-7
• Molecular Formula: C₁₅H₁₁NO₄
• Molecular Weight: 269.257
• Mol file: 128672-45-7.mol

Synonyms:trans-(2R,3S)-epoxy-3-(3-nitrophenyl)-1-phenyl-1-propan-1-one

Chemical Property of trans-(2R,3S)-epoxy-3-(3-nitrophenyl)-1-phenyl-1-propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-(2R,3S)-epoxy-3-(3-nitrophenyl)-1-phenyl-1-propan-1-one

There total 14 articles about trans-(2R,3S)-epoxy-3-(3-nitrophenyl)-1-phenyl-1-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-3-nitrochalcone (614-48-2,24721-24-2) → 2,3-epoxy-3-(3-nitrophenyl)-1-phenylpropan-1-one (18873-04-6,33037-08-0,128672-45-7)

Guidance literature:

With urea-2,2-dihydroperoxypropane; potassium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 1.3h; Green chemistry;

DOI:10.1007/s13738-016-0980-1

Reference yield: 94.0%

(E)-3-nitrochalcone (614-48-2,24721-24-2) → rac-((2R,3S)-3-(3-nitrophenyl)oxiran-2-yl)(phenyl)methanone (18873-04-6,33037-08-0,128672-45-7)

Guidance literature:

With trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; water; dihydrogen peroxide; potassium hydroxide; In 1,2-dimethoxyethane; at 20 ℃; for 2.5h;

DOI:10.1055/s-0030-1258996

Reference yield: 86.0%

3-nitrochalcone (614-48-2,24721-24-2) → rac-((2R,3S)-3-(3-nitrophenyl)oxiran-2-yl)(phenyl)methanone (18873-04-6,33037-08-0,128672-45-7)

Guidance literature:

3-nitrochalcone; With sodium hydroxide; In tetrahydrofuran; water; for 0.166667h;

With dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1055/s-0030-1260091

upstream raw materials:

3-nitro-benzaldehyde

α-bromoacetophenone

3-nitrochalcone

1-chloroacetophenone

Downstream raw materials:

3-nitrochalcone

5-(3-nitrophenyl)-1,3-diphenyl-1H-pyrazole

C₂₃H₁₈N₂O₄

[(4S,5R)-2,2-Dimethyl-5-(3-nitro-phenyl)-[1,3]dioxolan-4-yl]-phenyl-methanone