3070-65-3Relevant articles and documents
Efficient preparation of α,α-dialkyl-α-(phenylselanyl) acetates and α,β-unsaturated esters from the corresponding α,α-dialkyl-α-cyanoacetates by a lithium naphthalenide induced reductive selenenylation process
Ko, Yen-Chun,Zhu, Jia-Liang
, p. 3659 - 3665 (2008/09/19)
An array of α,α-dialkyl-α-(phenylselanyl)acetates has been synthesized very efficiently from readily available α,α- dialkyl-α-cyanoacetates, by use of lithium naphthalenide induced reductive α-selenenylation as a key operation. Moreover, the selanyl esters thus generated in situ could be converted further, in a one-pot treatment with hydrogen peroxide and acetic acid, into the corresponding α,β- unsaturated esters in moderate to high yields. The C=C bond formation was highly regio- and/or diastereoselective in some cases. Georg Thieme Verlag Stuttgart.
3-aryl-2-isoxazolines as antiinflammatory agents
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, (2008/06/13)
This invention relates to 3-aryl-2-isoxazoline compounds which are selective inhibitors of phosphodiesterase type IV (PDEIV). The 3-aryl-2-isoxazolines are useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulm
Preparation des organozinciques derives de l'α-bromomethyl acrylate d'ethyle et de ses homologues
Alami, Najat El,Belaud, Chantal,Villieras, Jean
, p. 1 - 10 (2007/10/02)
The preparation of the bromozinc derivatives of various α-bromoalkyl acrylates (aliphatic and alicyclic) results in high yields when carried out on 30 mesh activated granular zinc, between 14 and 20 deg C in ethereal solvents (THF, DME, ether).Under these conditions duplication can be minimized (5-15 percent) especially with t-butyl acrylates.These α-functional allylic orgazinc derivatives have been characterized by hydrolysis and coupling with benzaldehyde.
