C₁₈H₂₇ClN₂

Base Information

Chemical Name:C₁₈H₂₇ClN₂
CAS No.:1037359-96-8
Molecular Formula:C₁₈H₂₇ClN₂
Molecular Weight:306.879
Hs Code.:

C<sub>18</sub>H<sub>27</sub>ClN<sub>2</sub>

Synonyms:C₁₈H₂₇ClN₂

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Chemical Property of C₁₈H₂₇ClN₂

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Technology Process of C₁₈H₂₇ClN₂

There total 11 articles about C₁₈H₂₇ClN₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1037198-21-2
C₁₈H₂₅ClN₂O

: 1037359-96-8
C₁₈H₂₇ClN₂

Guidance literature:: C₁₈H₂₅ClN₂O; With borane-THF; In tetrahydrofuran; for 48h; Reflux;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 90 ℃; for 4h;
DOI:10.1016/j.bmcl.2013.12.118

Reference yield:

: 65619-29-6
1-(3-chlorophenyl)-4-oxocyclohexanecarbonitrile

: 1037359-96-8
C₁₈H₂₇ClN₂

Guidance literature:: Multi-step reaction with 10 steps

1.1: borane-THF / tetrahydrofuran / 4 h / Reflux

1.2: 16 h / 20 °C

2.1: triphenylphosphine; C₈H₁₄N₂O₄ / tetrahydrofuran / 20 h / 20 °C

3.1: sodium methylate / methanol; tetrahydrofuran / 15 h / 20 °C

4.1: triethylamine / dichloromethane / 16 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 5 h / 100 °C

6.1: triphenylphosphine / toluene; water / 20 h / 50 °C

7.1: sodium carbonate / chloroform; water / 0.75 h / 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

10.1: borane-THF / tetrahydrofuran / 48 h / Reflux

10.2: 4 h / 90 °C

With sodium azide; borane-THF; C₈H₁₄N₂O₄; sodium methylate; sodium hydride; sodium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; 2.1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.12.118

Reference yield:

: 1037235-79-2
[cis-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester

: 1037359-96-8
C₁₈H₂₇ClN₂

Guidance literature:: Multi-step reaction with 9 steps

1.1: triphenylphosphine; C₈H₁₄N₂O₄ / tetrahydrofuran / 20 h / 20 °C

2.1: sodium methylate / methanol; tetrahydrofuran / 15 h / 20 °C

3.1: triethylamine / dichloromethane / 16 h / 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 5 h / 100 °C

5.1: triphenylphosphine / toluene; water / 20 h / 50 °C

6.1: sodium carbonate / chloroform; water / 0.75 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

9.1: borane-THF / tetrahydrofuran / 48 h / Reflux

9.2: 4 h / 90 °C

With sodium azide; borane-THF; C₈H₁₄N₂O₄; sodium methylate; sodium hydride; sodium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; 1.1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.12.118