[trans-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[trans-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester
CAS No.:1037235-83-8
Molecular Formula:C₁₈H₂₆ClNO₃
Molecular Weight:339.862
Hs Code.:

Synonyms:[trans-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester

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Chemical Property of [trans-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester

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Technology Process of [trans-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester

There total 6 articles about [trans-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: C₂₅H₃₀ClNO₄

: 1037235-83-8
[trans-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester

Guidance literature:: With sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 15h;
DOI:10.1016/j.bmcl.2013.12.118

Reference yield:

: 1037235-81-6
2-fluorobenzoic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester

: 1037235-83-8
[trans-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester

Guidance literature:: 2-fluorobenzoic acid [trans-4-(tert-butoxycarbonylaminomethyl)-4-(3-chlorophenyl)cyclohexyl] ester; With methanol; sodium methylate; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; dichloromethane; water; pH=7;

Reference yield:

: 65619-29-6
1-(3-chlorophenyl)-4-oxocyclohexanecarbonitrile

: 1037235-83-8
[trans-1-(3-chlorophenyl)-4-hydroxycyclohexylmethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 4 h / Reflux

1.2: 16 h / 20 °C

2.1: triphenylphosphine; C₈H₁₄N₂O₄ / tetrahydrofuran / 20 h / 20 °C

3.1: sodium methylate / methanol; tetrahydrofuran / 15 h / 20 °C

With borane-THF; C₈H₁₄N₂O₄; sodium methylate; triphenylphosphine; In tetrahydrofuran; methanol; 2.1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.12.118