4-[5-(4-chlorophenyl)-3-(5-mercapto-[1,2,4]oxadiazol-3-yl)-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

Base Information

Chemical Name:4-[5-(4-chlorophenyl)-3-(5-mercapto-[1,2,4]oxadiazol-3-yl)-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide
CAS No.:1345041-97-5
Molecular Formula:C₁₇H₁₄ClN₅O₃S₂
Molecular Weight:435.915
Hs Code.:

Synonyms:4-[5-(4-chlorophenyl)-3-(5-mercapto-[1,2,4]oxadiazol-3-yl)-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

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Chemical Property of 4-[5-(4-chlorophenyl)-3-(5-mercapto-[1,2,4]oxadiazol-3-yl)-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

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Technology Process of 4-[5-(4-chlorophenyl)-3-(5-mercapto-[1,2,4]oxadiazol-3-yl)-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

There total 8 articles about 4-[5-(4-chlorophenyl)-3-(5-mercapto-[1,2,4]oxadiazol-3-yl)-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-15-0,12122-00-8
carbon disulfide

: C₁₈H₁₈ClN₅O₄S

: 1345041-97-5
4-[5-(4-chlorophenyl)-3-(5-mercapto-[1,2,4]oxadiazol-3-yl)-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.833333h;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 133678-11-2
ethyl 2-oxo-4-(p-chlorophenyl)but-3-enoate

: 1345041-97-5
4-[5-(4-chlorophenyl)-3-(5-mercapto-[1,2,4]oxadiazol-3-yl)-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: ammonium hydroxide / tetrahydrofuran; water / 50 - 60 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / 0.33 h / 0 °C

4.1: hydroxylamine hydrochloride; sodium carbonate / methanol / 6 h / 25 - 30 °C

5.1: triethylamine / dichloromethane / 2 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.83 h / 0 °C

With oxalyl dichloride; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; ammonium hydroxide; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 1345041-82-8
4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

: 1345041-97-5
4-[5-(4-chlorophenyl)-3-(5-mercapto-[1,2,4]oxadiazol-3-yl)-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium carbonate / methanol / 6 h / 25 - 30 °C

2: triethylamine / dichloromethane / 2 h / 20 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 0.83 h / 0 °C

With hydroxylamine hydrochloride; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1016/j.bmcl.2011.08.061