4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

Base Information

Chemical Name:4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide
CAS No.:1345041-82-8
Molecular Formula:C₁₆H₁₃ClN₄O₂S
Molecular Weight:360.824
Hs Code.:

Synonyms:4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

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Technology Process of 4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

There total 5 articles about 4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1345041-80-6
5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b)

: 1345041-82-8
4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

Guidance literature:: With oxalyl dichloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 133678-11-2
ethyl 2-oxo-4-(p-chlorophenyl)but-3-enoate

: 1345041-82-8
4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: ammonium hydroxide / tetrahydrofuran; water / 50 - 60 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / 0.33 h / 0 °C

With oxalyl dichloride; ammonium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 1000400-63-4
potassium 4-(4-chlorophenyl)-2-oxobut-3-enoate

: 1345041-82-8
4-[5-(4-chlorophenyl)-3-cyano-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 0 °C / Reflux

2.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

2.2: 10 h / Inert atmosphere; Reflux

3.1: ammonium hydroxide / tetrahydrofuran; water / 50 - 60 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / 0.33 h / 0 °C

With thionyl chloride; oxalyl dichloride; ammonium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.061