5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b)

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b)
CAS No.:1345041-80-6
Molecular Formula:C₁₆H₁₅ClN₄O₃S
Molecular Weight:378.839
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b)

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Chemical Property of 5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b)

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Technology Process of 5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b)

There total 4 articles about 5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1345041-76-0
5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

: 1345041-80-6
5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b)

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; water; at 50 - 60 ℃;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 133678-11-2
ethyl 2-oxo-4-(p-chlorophenyl)but-3-enoate

: 1345041-80-6
5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b)

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: ammonium hydroxide / tetrahydrofuran; water / 50 - 60 °C

With ammonium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 1000400-63-4
potassium 4-(4-chlorophenyl)-2-oxobut-3-enoate

: 1345041-80-6
5-(4-chlorophenyl)-1-(4-sulfamoyl-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid amide (4b)

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 0 °C / Reflux

2.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

2.2: 10 h / Inert atmosphere; Reflux

3.1: ammonium hydroxide / tetrahydrofuran; water / 50 - 60 °C

With thionyl chloride; ammonium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmcl.2011.08.061