5-[2-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitroisoxazole

Base Information

• Chemical Name: 5-[2-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitroisoxazole
• CAS No.: 914482-18-1
• Molecular Formula: C₁₇H₁₇ClN₄O₃
• Molecular Weight: 360.8
• Mol file: 914482-18-1.mol

Synonyms:5-[2-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitroisoxazole

Chemical Property of 5-[2-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitroisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[2-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitroisoxazole

There total 5 articles about 5-[2-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[1-(4-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl]pentane-2,4-dione (79510-59-1) → 5-[2-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitroisoxazole (914482-18-1)

Guidance literature:

With hydrazine; In ethanol; at 65 ℃; for 7h;

DOI:10.1021/ol062151y

Reference yield:

3,5-dimethyl-4-nitroisoxazole (1123-49-5) → 5-[2-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitroisoxazole (914482-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / ethanol / 1 h / 60 °C

2: ethanol / 6 h / 60 °C

3: 1021 mg / NH₂-NH₂ / ethanol / 7 h / 65 °C

With piperidine; hydrazine; In ethanol;

DOI:10.1021/ol062151y

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 5-[2-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitroisoxazole (914482-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / ethanol / 1 h / 60 °C

2: ethanol / 6 h / 60 °C

3: 1021 mg / NH₂-NH₂ / ethanol / 7 h / 65 °C

With piperidine; hydrazine; In ethanol;

DOI:10.1021/ol062151y

upstream raw materials:

3-[1-(4-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl]pentane-2,4-dione

3,5-dimethyl-4-nitroisoxazole

4-chlorobenzaldehyde

acetylacetone