Technology Process of C16H22O2
There total 9 articles about C16H22O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
1,2-dichloro-ethane;
at 20 - 40 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/ol4028418
- Guidance literature:
-
methylmagnesium bromide;
With
copper(l) iodide;
In
tetrahydrofuran;
at -30 - 0 ℃;
for 1.5h;
C15H18O2;
In
tetrahydrofuran;
at -30 ℃;
for 3h;
Further stages.;
DOI:10.1055/s-2007-982563
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: {Cu[(S,S)-tert-Bu-box]}(H2O)2(SbF6)2 / CH2Cl2; 2,2,2-trifluoro-ethanol / 72 h / 20 °C
1.2: K[(sec-Bu)3BH] / CH2Cl2 / -100 °C
1.3: 27.6 mg / second-generation Grubbs catalyst / 1,2-dichloro-ethane / 5 h / 40 °C
2.1: 94 percent / LiBH4 / tetrahydrofuran / 2 h / 0 °C
3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
3.2: 80 percent / 1-(p-Me-C6H4-SO2)-imidazole / tetrahydrofuran / 1 h / 20 °C
4.1: CuI / tetrahydrofuran / 1.5 h / -30 - 0 °C
4.2: 92 percent / tetrahydrofuran / 3 h / -30 °C
With
copper(l) iodide; lithium borohydride; sodium hydride;
{Cu[(S,S)-tert-Bu-box]}(H2O)2(SbF6)2;
In
tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol;
1.1: catalytic asymmetric Claisen rearrangement;
DOI:10.1055/s-2007-982563
